| Identification | Back Directory | [Name]
Benzamide, N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)- | [CAS]
924636-93-1 | [Synonyms]
Benzamide, N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)- | [Molecular Formula]
C22H17F3N2O | [MOL File]
924636-93-1.mol | [Molecular Weight]
382.38 |
| Hazard Information | Back Directory | [Description]
AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE(2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH(2) metabolism towards other terminal PG synthases in monocytes. The functional relevance of this observation deserves to be investigated in vivo. |
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