924377-85-5
中文名稱
1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
英文名稱
1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
CAS
924377-85-5
分子式
C22H25N3O2S
分子量
395.52
MOL 文件
924377-85-5.mol
924377-85-5 結構式
基本信息
中文別名
化合物 T15425 英文別名
GSK 1702934A1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
常見問題列表
生物活性
GSK1702934A是一種選擇性的 TRPC3 激動劑。GSK1702934A 通過激活 TRPC3 調節(jié)心臟收縮力和心律失常。靶點
|
TRPC3
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體外研究
GSK1702934A is able to induce TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6 with an EC
50
of 0.08 mM and 0.44 mM, respectively.
GSK1702934A induces a transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes but not in wild-type myocytes.
GSK1702934A substantially promotes NCX currents in TRPC3-overexpressing myocytes.
體內研究
GSK1702934A (0.3-3 mg/kg; i.v.) transiently increases blood pressure by 15 ~ 35 mmHg in conscious Sprague Dawley rats.