886563-25-3
886563-25-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13402 英文別名
ZK-991ZK 991
ZK-261991
ZK261991(ZK991)
ZK261991
ZK-261991
ZK 261991
ZK-991
ZK 991
Benzamide, 2-[[[2-[[(dimethylamino)carbonyl]amino]-4-pyridinyl]methyl]amino]-N-(2-methyl-2H-indazol-6-yl)-
常見問題列表
生物活性
ZK-261991 是一種可口服的 VEGFR 酪氨酸酶抑制劑，抑制 VEGFR-2 活性的 IC50 值為 5 nM。靶點
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VEGFR2 5 nM (IC 50 ) |
體外研究
ZK-261991 inhibits cellular receptor autophosphorylation in KDR-PAECs with an IC 50 of 2 nM. ZK991 inhibits VEGFR-3 autophosphorylation concentration dependently with an IC 50 of 20 nM.
體內(nèi)研究
ZK991 results in a significantly reduced recruitment of CD11b + and LYVE-1 + cells into the murine cornea. ZK991 significantly improves the graft survival rate after corneal transplantation.