186371-96-0
中文名稱
FUDAEUIGIJZUAY-UMIRZPQISA-N
英文名稱
FUDAEUIGIJZUAY-UMIRZPQISA-N
CAS
186371-96-0
分子式
C32H46O5
分子量
510.7
MOL 文件
186371-96-0.mol
186371-96-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)652.9±55.0 °C(Predicted)
密度1.15±0.1 g/cm3(Predicted)
儲(chǔ)存條件4°C, protect from light, stored under nitrogen
酸度系數(shù)(pKa)14.29±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
FUDAEUIGIJZUAY-UMIRZPQISA-N價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-12407 | FUDAEUIGIJZUAY-UMIRZPQISA-N ZK168281 | 186371-96-0 | 1mg | 8500元 |
常見(jiàn)問(wèn)題列表
生物活性
ZK168281 是一種 1α,25(OH)2D3 類似物，也是一種純 VDR 拮抗劑，Kd 值為 0.1 nM。ZK168281 是其受體 CoA 相互作用的有效抑制劑。靶點(diǎn)
Kd: 0.1 nM (VDR)
體外研究
ZK168281 resembles more the mouse constitutive androstane receptor (CAR) inverse agonist Androstanol in its ability to recruit corepressor (CoR) proteins. A salt bridge between the CoR and a conserved lysine in helix 4 of the nuclear receptor (NR) is central to this interaction, but also helix 12 was stabilized by direct contacts with residues of the CoR. Fixation of helix 12 in the antagonistic/inverse agonistic conformation prevents an energetically unfavorable free floatation of the C terminus.