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86393-32-0

中文名稱 鹽酸環(huán)丙沙星(一水物)
英文名稱 Ciprofloxacin hydrochloride hydrate
CAS 86393-32-0
分子式 C17H21ClFN3O4
MDL 編號(hào) MFCD00079044
分子量 385.82
MOL 文件 86393-32-0.mol
更新日期 2024/12/24 16:34:48
86393-32-0 結(jié)構(gòu)式 86393-32-0 結(jié)構(gòu)式

基本信息

中文別名
鹽酸環(huán)丙沙星歐洲藥典標(biāo)準(zhǔn)品
環(huán)丙沙星鹽酸
環(huán)丙沙星HCL
1-環(huán)丙基-6-氟-1,4-二氫-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸鹽酸鹽一水物
鹽酸環(huán)丙沙星(一水物)
英文別名
3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE
CIPROFLOXACIN HCL
CIPROFLOXACIN HYDROCHLORIDE
CIPROFLOXACIN HCL/ CIPROFLOXACIN MONOHYDROCHLORIDE
CIPROFLOXACIN HCL USP
CIPROFLOXACINHYDROCHLORIDE,USP
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride hydrate
Ciprofloxacin hydrochloride hydrate
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride monohydrate
所屬類別
原料藥:其它抗生素類藥

物理化學(xué)性質(zhì)

外觀性狀白色或微黃色結(jié)晶粉末。易溶于水,微溶于甲醇,難溶于乙醇。
熔點(diǎn)318-320 °C
RTECS號(hào)VB1993800
儲(chǔ)存條件0-6°C
溶解度Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol, practically insoluble in acetone, in ethyl acetate and in methylene chloride.
形態(tài)neat
顏色White to Light yellow
PH值pH (25g/l, 25℃) 3.0~4.5
水溶解性Soluble in water (35mg/ml).
Merck2314
InChIKeyDIOIOSKKIYDRIQ-UHFFFAOYSA-N
CAS 數(shù)據(jù)庫86393-32-0(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
WGK Germany3
危險(xiǎn)等級(jí)IRRITANT
海關(guān)編碼2933595960

應(yīng)用領(lǐng)域

用途一
該品為廣譜抗生素。通過抑制細(xì)菌DNA旋轉(zhuǎn)酶,使DNA合成和復(fù)制受阻而導(dǎo)致細(xì)菌死亡。對(duì)大腸桿菌、克雷白桿菌和其他腸桿菌屬有較強(qiáng)抗菌活性;對(duì)綠膿桿菌、金黃色葡萄球菌和肺炎鏈球菌的抗菌作用優(yōu)于諾氟沙星和培氟沙星。用于敏感菌所致的中耳炎、外耳道炎和鼓膜炎等。偶有中耳痛及瘙癢感。
用途二
該品味廣譜抗生素。通過抑制細(xì)菌DNA旋轉(zhuǎn)酶,使DNA合成和復(fù)制受阻而導(dǎo)致細(xì)菌死亡。對(duì)大腸桿菌,克雷白桿菌和其他腸桿菌屬有較強(qiáng)抗菌活性、對(duì)綠膿桿菌、金黃色葡萄球菌和肺炎鏈球菌的抗菌作用優(yōu)于諾氟沙星和培氟沙星。用于敏感菌所致的中耳炎,外耳道炎和骨膜炎等。偶有中耳痛及瘙癢感。
鹽酸環(huán)丙沙星(一水物)價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08C2227環(huán)丙沙星鹽酸鹽一水合物
Ciprofloxacin Hydrochloride  Monohydrate
86393-32-05G200元
2024/11/08C2227環(huán)丙沙星鹽酸鹽一水合物
Ciprofloxacin Hydrochloride  Monohydrate
86393-32-025G330元
2024/11/08C2227環(huán)丙沙星鹽酸鹽 一水合物
Ciprofloxacin Hydrochloride Monohydrate
86393-32-0100g990元

常見問題列表

生物活性
Ciprofloxacin Hydrochloride (Ciloxan, Ceprimax, Oftacilox) 是ciprofloxacin的鹽酸鹽形式,ciprofloxacin是一種抗生素,用于治療一些細(xì)菌感染疾病。
體外研究

Ciprofloxacin (hydrochloride monohydrate) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin (hydrochloride monohydrate) (CIP) shows potent activity against Y. pestis with MIC 90 of 0.03 μg/mL.

體內(nèi)研究

Ciprofloxacin (hydrochloride monohydrate) (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (hydrochloride monohydrate) (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae. In a murine model of pneumonic plague, Ciprofloxacin (hydrochloride monohydrate) (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin (hydrochloride monohydrate). Intraperitoneal Ciprofloxacin (hydrochloride monohydrate) reduces the lung bacterial load compare to controls treated with intraperitoneal PBS.

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