856307-27-2
基本信息
安乃近雜質(zhì)C(EP)
4-甲氨基安替比林鹽酸鹽
安乃近雜質(zhì)C(EP) 標(biāo)準(zhǔn)品
N-甲基-4-氨基安替比林鹽酸鹽
4-METHYLAMINOANTIPYRINE HYDROCHLORIDE
Metamizole EP Impurity C HCl
4-Methylamino-1,5-dimethyl-2-phenyl
4-Methylaminoantipyrine hydrochloride
N-Methyl-4-aminoantipyrine Hydrochloride
Antipyrine,4-(methylamino)-, hydrochloride
MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl
1,5-dimethyl-4-(methylamino)-2-phenylpyrazol-3-one:hydrochloride
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-, hydrochloride
物理化學(xué)性質(zhì)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/04/30 | HY-135731A | 安乃近雜質(zhì)C 4-Methylamino antipyrine hydrochloride | 856307-27-2 | 100mg | 2450元 |
2024/01/25 | HY-135731A | 安乃近雜質(zhì)C 4-Methylamino antipyrine hydrochloride | 856307-27-2 | 25mg | 1050元 |
2024/01/25 | HY-135731A | 安乃近雜質(zhì)C 4-Methylamino antipyrine hydrochloride | 856307-27-2 | 50mg | 1550元 |
常見問題列表
COX
Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important.
The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine.