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856307-27-2

中文名稱 安乃近雜質(zhì)C
英文名稱 MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl
CAS 856307-27-2
分子式 C12H16ClN3O
分子量 253.728
MOL 文件 856307-27-2.mol
更新日期 2023/03/20 15:41:21
856307-27-2 結(jié)構(gòu)式 856307-27-2 結(jié)構(gòu)式

基本信息

中文別名
安乃近雜質(zhì)C
安乃近雜質(zhì)C(EP)
4-甲氨基安替比林鹽酸鹽
安乃近雜質(zhì)C(EP) 標(biāo)準(zhǔn)品
N-甲基-4-氨基安替比林鹽酸鹽
4-METHYLAMINOANTIPYRINE HYDROCHLORIDE
英文別名
Metamizole EP Impurity C
Metamizole EP Impurity C HCl
4-Methylamino-1,5-dimethyl-2-phenyl
4-Methylaminoantipyrine hydrochloride
N-Methyl-4-aminoantipyrine Hydrochloride
Antipyrine,4-(methylamino)-, hydrochloride
MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl
1,5-dimethyl-4-(methylamino)-2-phenylpyrazol-3-one:hydrochloride
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-, hydrochloride

物理化學(xué)性質(zhì)

熔點>195°C
儲存條件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度可溶于氯仿(輕微,超聲處理)、DMSO(輕微)、水(輕微)
形態(tài)固體
顏色淺橙色至淺棕色
穩(wěn)定性吸濕性
安乃近雜質(zhì)C價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/04/30HY-135731A安乃近雜質(zhì)C
4-Methylamino antipyrine hydrochloride
856307-27-2100mg2450元
2024/01/25HY-135731A安乃近雜質(zhì)C
4-Methylamino antipyrine hydrochloride
856307-27-225mg1050元
2024/01/25HY-135731A安乃近雜質(zhì)C
4-Methylamino antipyrine hydrochloride
856307-27-250mg1550元

常見問題列表

生物活性
4-Methylamino antipyrine hydrochloride 是一種 Metamizole 的活性代謝產(chǎn)物。Metamizole 是吡唑啉酮類非甾體抗炎藥 (NSAID),是一種有效的 COX 抑制劑。Metamizole 是一種非阿片類鎮(zhèn)痛藥,可用于疼痛和發(fā)燒。4-Methylamino antipyrine hydrochloride 具有止痛,解熱和相對較弱的抗炎特性。
靶點

COX

體外研究

Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important.

體內(nèi)研究

The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine.

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