Identification | Back Directory | [Name]
MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl | [CAS]
856307-27-2 | [Synonyms]
Metamizole EP Impurity C Metamizole EP Impurity C HCl 4-Methylamino-1,5-dimethyl-2-phenyl 4-Methylaminoantipyrine hydrochloride N-Methyl-4-aminoantipyrine Hydrochloride Antipyrine,4-(methylamino)-, hydrochloride MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl 1,5-dimethyl-4-(methylamino)-2-phenylpyrazol-3-one:hydrochloride 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-, hydrochloride | [Molecular Formula]
C12H16ClN3O | [MDL Number]
MFCD16620361 | [MOL File]
856307-27-2.mol | [Molecular Weight]
253.728 |
Chemical Properties | Back Directory | [Melting point ]
>195°C | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly, Sonicated), DMSO (Slightly), Water (Slightly) | [form ]
Solid | [color ]
Pale Orange to Light Brown | [Stability:]
Hygroscopic |
Hazard Information | Back Directory | [Uses]
4-Methylaminoantipyrine Hydrochloride is a useful research chemical, a methylamino antipyrine derivatives. | [Biological Activity]
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. It has analgesic, antipyretic and relatively weak anti-inflammatory properties. | [in vitro]
Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important. | [in vivo]
The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of it is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine. < p> | [target]
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