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ChemicalBook--->CAS DataBase List--->856307-27-2

856307-27-2

856307-27-2 Structure

856307-27-2 Structure
IdentificationBack Directory
[Name]

MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl
[CAS]

856307-27-2
[Synonyms]

Metamizole EP Impurity C
Metamizole EP Impurity C HCl
4-Methylamino-1,5-dimethyl-2-phenyl
4-Methylaminoantipyrine hydrochloride
N-Methyl-4-aminoantipyrine Hydrochloride
Antipyrine,4-(methylamino)-, hydrochloride
MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl
1,5-dimethyl-4-(methylamino)-2-phenylpyrazol-3-one:hydrochloride
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-, hydrochloride
[Molecular Formula]

C12H16ClN3O
[MDL Number]

MFCD16620361
[MOL File]

856307-27-2.mol
[Molecular Weight]

253.728
Chemical PropertiesBack Directory
[Melting point ]

>195°C
[storage temp. ]

Hygroscopic, -20°C Freezer, Under inert atmosphere
[solubility ]

Chloroform (Slightly, Sonicated), DMSO (Slightly), Water (Slightly)
[form ]

Solid
[color ]

Pale Orange to Light Brown
[Stability:]

Hygroscopic
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
Hazard InformationBack Directory
[Uses]

4-Methylaminoantipyrine Hydrochloride is a useful research chemical, a methylamino antipyrine derivatives.
[Biological Activity]

4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. It has analgesic, antipyretic and relatively weak anti-inflammatory properties.
[in vitro]

Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important.

[in vivo]

The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of it is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine.

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[target]

COX

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