80665-72-1
中文名稱
附子靈
英文名稱
Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)- , (1alpha,6alpha,14alpha,15alpha,16beta)-
CAS
80665-72-1
分子式
C24H39NO7
分子量
453.58
MOL 文件
80665-72-1.mol
更新日期
2025/04/03 15:13:38
80665-72-1 結(jié)構(gòu)式
基本信息
中文別名
附子寧附子靈對照品
FUZILINE 附子靈
英文別名
Senbusine C15-Epinagarine
15-Hydroxyneoline
15-α-hydroxyneoline
Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)- ,
Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-, (1α,6α,14α,15α,16β)-
Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)- , (1alpha,6alpha,14alpha,15alpha,16beta)-
物理化學性質(zhì)
外觀性狀白色晶體，可溶于甲醇、乙醇、DMSO等有機溶劑，來源于生附子、毛茛科植物烏頭子根的加工品。
熔點206-207℃
沸點596.9±50.0 °C(Predicted)
密度1.36±0.1 g/cm3 (20 ºC 760 Torr)
溶解度Chloroform: soluble; DMSO: soluble
酸度系數(shù)(pKa)12.78±0.70(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
常見問題列表
生物活性
Fuziline 是一種從附子側(cè)根中分離得到的生物堿。體外研究
Fuziline shows activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability.
體內(nèi)研究
Fuziline exhibits the mean half-life of 5.93 hours, 6.13 hours and 5.12?hours for 14?mg/kg, 2 4?mg/kg and 4?mg/kg, respectively, by oral administration in rat.