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78441-82-4

中文名稱 BMY-25271
英文名稱 N-[2-[[[5-[(Dimethylamino)methyl]furan-2-yl]methyl]thio]ethyl]-1,2,5-thiadiazole-3,4-diamine1-oxide
CAS 78441-82-4
分子式 C12H19N5O2S2
分子量 329.44
MOL 文件 78441-82-4.mol
78441-82-4 結(jié)構(gòu)式 78441-82-4 結(jié)構(gòu)式

基本信息

中文別名
化合物 T10575
英文別名
BMY-25271
N-[2-[[[5-[(Dimethylamino)methyl]furan-2-yl]methyl]thio]ethyl]-1,2,5-thiadiazole-3,4-diamine1-oxide
1,2,5-Thiadiazole-3,4-diamine, N3-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-, 1-oxide

物理化學(xué)性質(zhì)

儲存條件-20°C儲存
溶解度溶于二甲基亞砜

常見問題列表

生物活性
BMY-25271 是一個組胺 H2 受體 (histamine H2 receptor) 拮抗劑。
靶點

Histamine H2 receptor

體內(nèi)研究

BMY-25271 is a histamine H2 receptor antagonist. The dose response curves are parallel and oral ED 50 values derived from probit analysis are 0.093, 0.97 and 6.9 mg/kg for BMY-25271, ranitidine and cimetidine, respectively. BMY-25271, therefore, is about 10 and 74 times more potent than ranitidine and cimetidine, respectively. Pretreatment with the highest dose of BMY-25271 does not significantly affect the absorption of aspirin or the formation of its major metabolite, salicylic acid.

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