| Identification | Back Directory | [Name]
N-[2-[[[5-[(Dimethylamino)methyl]furan-2-yl]methyl]thio]ethyl]-1,2,5-thiadiazole-3,4-diamine1-oxide | [CAS]
78441-82-4 | [Synonyms]
BMY-25271
N-[2-[[[5-[(Dimethylamino)methyl]furan-2-yl]methyl]thio]ethyl]-1,2,5-thiadiazole-3,4-diamine1-oxide
1,2,5-Thiadiazole-3,4-diamine, N3-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-, 1-oxide | [Molecular Formula]
C12H19N5O2S2 | [MDL Number]
MFCD30533313 | [MOL File]
78441-82-4.mol | [Molecular Weight]
329.44 |
| Hazard Information | Back Directory | [Uses]
BMY-25271 is a histamine H2 receptor antagonist. | [Biological Activity]
BMY-25271 is a histamine H2 receptor antagonist. | [in vivo]
BMY-25271 is a histamine H2 receptor antagonist. The dose response curves are parallel and oral ED 50 values derived from probit analysis are 0.093, 0.97 and 6.9 mg/kg for BMY- 25271, ranitidine and cimetidine, respectively. Therefore it is about 10 and 74 times more potent than ranitidine and cimetidine, respectively. | [target]
| [IC 50]
H2 Receptor | [References]
[1] Cavanagh RL, et al. Prevention of aspirin-induced gastric mucosal injury by histamine H2 receptor antagonists: a crossover endoscopic and intragastric pH study in the dog. J Pharmacol Exp Ther. 1987 Dec;243(3):1179-84. PMID:2891837 |
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