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77465-10-2

中文名稱 ACTH (1-39) (MOUSE, RAT)
英文名稱 ADRENOCORTICOTROPIC HORMONE RAT
CAS 77465-10-2
分子式 C210H315N57O57S1
分子量 4582.16
更新日期 2024/10/29 09:42:23
77465-10-2 結(jié)構(gòu)式 77465-10-2 結(jié)構(gòu)式

基本信息

中文別名
SF-39
大鼠 ACTH (1-39) 肽
英文別名
ACTH 1-39
CORTICOTROPIN A
ACTH (1-39) (RAT)
ACTH (1-39) (MOUSE, RAT)
α1-39-Corticotropin (rat)
ADRENOCORTICOTROPIC HORMONE RAT
ADRENOCORTICOTROPIC HORMONE (1-39) (RAT)
Adrenocorticotropic Hormone (ACTH) (1-39), rat
SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-VAL-ALA-GLU-ASN-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE
H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-VAL-ALA-GLU-ASN-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE-OH
所屬類別
生物化工:抑制劑

物理化學(xué)性質(zhì)

儲(chǔ)存條件−20°C
溶解度Soluble in DMSO
形態(tài)Solid
序列H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Val-Ala-Glu-Asn-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
警示詞警告
危險(xiǎn)性描述H302+H312+H332-H351
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼20/21/22-40
安全說明22-36
WGK Germany3

常見問題列表

生物活性
Adrenocorticotropic Hormone (ACTH) (1-39), rat 是一種有效的黑皮質(zhì)素 2 型受體 (melanocortin 2 receptor, MC2) 激動(dòng)劑。
靶點(diǎn)

Melanocortin 2 receptor

體外研究

ACTH 1-39 at concentrations of 100-400 nM has no toxic effect on neurons, while ACTH provides protection from excitotoxic neuronal death induced by glutamate (100 μM), NMDA (1 mM), AMPA (50 μM), and kainate (25 μM). ACTH at 400 nM provides substantial protection in each case. ACTH at either 200 or 400 nM protects neurons from quinolinic acid (25 μM). There is also protection by ACTH from cell death induced by 2 μM H 2 O 2 , which gives rise to reactive oxygen species (ROS), with significantly more protection at 400 nM ACTH compared to 200 nM. ACTH gives modest protection against rapid release of nitric oxide (NO) by NOC-12 but not slow release by NOC-18. ACTH (200 or 400 nM) protects neurons from cytotoxic effects of staurosporine (10-20 nM), a classic inducer of cell death via apoptosis. ACTH reduces cell death from 80% to 55%.

體內(nèi)研究

The icv injection of ACTH significantly reduces cumulative food intake over the observation period compared with the saline/IgG group. The injection of ACTH Ab into the PVN abolishes the anorexigenic effect of ACTH. Infusion icv of ACTH significantly decreases cumulative food intake in rats that receive α-MSH Ab into the PVN and ACTH icv, and food intake is as low as in the group treated with ACTH icv and IgG into the PVN. Injection of either ACTH Ab or α-MSH Ab into the PVN significantly increase cumulative food intake compared with IgG-treated animals; the combined application of both Ab’s do not increase food intake further.

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