4237-93-8
中文名稱
促腎上腺皮質(zhì)激素-(11-24)-十四肽
英文名稱
ADRENOCORTICOTROPIC HORMONE, FRAGMENT 11-24
CAS
4237-93-8
分子式
C77H134N24O16
分子量
1652.04
MOL 文件
4237-93-8.mol
更新日期
2024/10/20 11:23:31
4237-93-8 結(jié)構(gòu)式
基本信息
中文別名
促腎上腺皮質(zhì)激素-(11-24)-十四肽 英文別名
(11-24)-ACTHbeta11-24-ACTH
alpha11-24-ACTH
Human ACTH(11-24)
α11-24-Corticotropin
Adrenocorticotropic Hormone (11-24)
Corticotropin-(11-24)-tetradecapeptide
human adrenocorticotropic hormone (11-24)
adrenocorticotropic hormone fragment 11-24, human
ACTH (11-24) H-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
物理化學(xué)性質(zhì)
儲(chǔ)存條件Store at -20°C, protect from light, stored under nitrogen
形態(tài)固體
顏色White to off-white
水溶解性溶于水
常見(jiàn)問(wèn)題列表
生物活性
ACTH (11-24) 是促腎上腺皮質(zhì)激素的多肽片段，為促腎上腺皮質(zhì)激素 (ACTH) 受體拮抗劑，能夠促進(jìn)皮質(zhì)醇的釋放。靶點(diǎn)
Adrenocorticotropic hormone receptor
體外研究
ACTH (11-24) acts as an antagonist of adrenocorticotropic hormone receptor. ACTH (11-24) induces cortisol secretion submaximally in freshly dispersed or cultured beef adrenal cortical cells. The maximal cortisol release by ACTH (11-24) is enhanced by forskolin but inhibited by calcium channel blockers.
體內(nèi)研究
ACTH (11-24) blocks electroacupuncture (EA) anti-edema but not EA anti-hyperalgesia in rats.