773-76-2
中文名稱(chēng)
5,7-二氯-8-羥基喹啉
英文名稱(chēng)
5,7-Dichloro-8-hydroxyquinoline
CAS
773-76-2
EINECS 編號(hào)
212-258-3
分子式
C9H5Cl2NO
MDL 編號(hào)
MFCD00006786
分子量
214.05
MOL 文件
773-76-2.mol
更新日期
2024/12/31 13:24:03
773-76-2 結(jié)構(gòu)式
基本信息
中文別名
5,7-二氯-8-羥基喹啉5,7-二氯-8-羧基喹啉
5,7-二氯-8-羥基氮雜萘
[克]氯辛
英文別名
5,7-DICHLORO-8-HYDROXYQUINOLINE5,7-DICHLORO-8-OXINE
5,7-DICHLORO-8-QUINOLINOL
AKOS BBS-00002684
CHLOROXINE
5,7-Dichlor-8-hydroxychinolin
5,7-Dichloro-8-hydroquinoline
5,7-Dichloro-8-hydroxyquinolin
5,7-Dichloro-8-oxychinolin
5,7-Dichloro-8-oxyquinoline
5,7-dichloro-8-quinolino
5,7-Dichlorooxine
5,7-Dichloroxine
8-Quinolinol,5,7-dichloro-
Capitrol
Chhoroox-ine
Chlofucid
CHQ
Clofuzid
component of Capitrol Cream Shampoo
所屬類(lèi)別
醫(yī)藥中間體：喹啉類(lèi)化合物物理化學(xué)性質(zhì)
外觀性狀無(wú)色或淡黃色針狀結(jié)晶。熔點(diǎn)180-181℃。溶于苯、丙酮、醚、二硫化碳、乙醇和濃硫酸，不溶于水，易溶于氫氧化鈉、氫氧化鉀呈黃色溶液。
熔點(diǎn)178-180 °C(lit.)
沸點(diǎn)305.47°C (rough estimate)
密度1.3320 (rough estimate)
折射率1.5500 (estimate)
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated)
酸度系數(shù)(pKa)2.30±0.30(Predicted)
形態(tài)蓬松粉末
顏色淺米色
Merck14,2175
BRN153606
穩(wěn)定性Light Sensitive
CAS 數(shù)據(jù)庫(kù)773-76-2(CAS DataBase Reference)
NIST化學(xué)物質(zhì)信息8-Quinolinol, 5,7-dichloro-(773-76-2)
EPA化學(xué)物質(zhì)信息8-Quinolinol, 5,7-dichloro- (773-76-2)
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H302-H315-H318-H335
危險(xiǎn)品標(biāo)志Xn,Xi
危險(xiǎn)類(lèi)別碼R22-R37/38-R41-R36/37/38
安全說(shuō)明S26-S36-S37/39-S25-S22
WGK Germany3
RTECS號(hào)VC5350000
TSCAYes
海關(guān)編碼29334900
制備方法
方法一
由8-羥基喹啉經(jīng)氯化而得。將10g8-羥基喹啉溶于100g冰醋酸中，然后通過(guò)氯氣直至溶液成為金黃色為止。將反應(yīng)物注入1升水中，即析出5g7-二氯-8-羥基喹啉，過(guò)濾后用200ml丙酮重結(jié)晶而得成品。5,7-二氯-8-羥基喹啉價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | 11343 | 5,7-二氯-8-羥基喹啉,98% 5,7-Dichloro-8-hydroxyquinoline, 98%, Thermo Scientific Chemicals | 773-76-2 | 5g | 282元 |
| 2024/11/08 | 11343 | 5,7-二氯-8-羥基喹啉,98% 5,7-Dichloro-8-hydroxyquinoline, 98%, Thermo Scientific Chemicals | 773-76-2 | 5g | 282元 |
| 2024/11/08 | S1839 | 5,7-二氯-8-羥基喹啉 Chloroxine | 773-76-2 | 50mg | 780.23元 |
常見(jiàn)問(wèn)題列表
生物活性
Chloroxine是一種人工合成的抗菌化合物，加入洗發(fā)液中，有效治療頭皮屑和脂溢性皮炎。靶點(diǎn)
Bacterial
體外研究
By using the Jouyban-Acree model, the Chloroxine solubility is well correlated obtaining RAD values lower than 3.64% and RMSD values lower than 8.82?×?10 ?6 . Chloroxine is preferentially solvated by water for the studied mixtures in water-rich compositions; while within intermediate and co-solvent-rich compositions, Chloroxine is preferentially solvated by DMSO (DMF, NMP or 1,4-dioxane) in DMSO (DMF, NMP or 1,4-dioxane)?+?water mixtures. It is shown that the change in solvent-solvent interaction energy accounted by cavity term governed the solubility variation of Chloroxine in all aqueous mixtures.