76-80-2
76-80-2 結(jié)構(gòu)式
基本信息
中文別名
灰葉素灰葉草素, 羥基魚藤素
英文別名
Deguelinol IIsotephrosin
Hydroxydeguelin
Tephrosin (synthetic)
(-)-TEPHROSIN USP/EP/BP
Tephrosin >=95% (LC/MS-ELSD)
13,13a-Dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
3H-Bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7- (7aH)-one,13,13a-dihydro-7a-hydroxy-9,10- dimethoxy-3,3-dimethyl-,(7aR,13aR)-
所屬類別
生物化工：中草藥成分物理化學(xué)性質(zhì)
熔點(diǎn)198° (218-220°)
沸點(diǎn)450.42°C (rough estimate)
密度1.2284 (rough estimate)
折射率1.5300 (estimate)
儲存條件-20°C
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)10.47±0.40(Predicted)
形態(tài)Cryst.
顏色White to off-white
常見問題列表
生物活性
Tephrosin 是一種天然類胡蘿卜素，具有較強(qiáng)的抗腫瘤活性。Tephrosin 通過誘導(dǎo)受體內(nèi)化來誘導(dǎo) EGFR 和 ErbB2 的降解。體外研究
Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) .