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681006-28-0

中文名稱 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽
英文名稱 AICAR (phosphate)
CAS 681006-28-0
分子式 C9H17N4O9P
分子量 356.226
MOL 文件 681006-28-0.mol
更新日期 2024/11/15 18:20:32
681006-28-0 結(jié)構(gòu)式 681006-28-0 結(jié)構(gòu)式

基本信息

中文別名
阿卡地新磷酸鹽
阿卡地新磷酸鹽?, >98%
5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽
英文別名
AICAR (phosphate)
Acadesine phosphate
AICAR phosphate, >98%
AICA Riboside phosphate)
AICAR (Acadesine) phosphate
AICAR phosphate (Acadesine phosphate
ACADESINE PHOSPHATE
AICA RIBOSIDE PHOSPHATE
5-Amino-1-ribosylimidazole-4-carboxamide phosphate
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
形態(tài)Solid
顏色White to off-white
5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-13417A5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽
AICAR phosphate
681006-28-050mg520元
2024/11/08HY-13417A5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽
AICAR phosphate
681006-28-010mM * 1mLin Water572元
2024/11/08HY-13417A5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽
AICAR phosphate
681006-28-0100mg860元

常見(jiàn)問(wèn)題列表

生物活性
AICAR phosphate (Acadesine phosphate) 是一種腺苷類似物,也是一種 AMPK 激活劑。AICAR phosphate 調(diào)節(jié)葡萄糖和脂質(zhì)的代謝,并抑制促炎細(xì)胞因子和 iNOS 的產(chǎn)生。AICAR phosphate 也是一種自噬 (autophagy),YAP 和 mitophagy 抑制劑。
靶點(diǎn)

AMPK

Autophagy

Mitophagy

體外研究

HepG2 cells are treated with various concentrations of AICAR (0.1-1.0 mM) for 12, 24, and 48 h, respectively. The expression level of IR-β significantly decreases with 0.25, 0.5, and 1.0 mM of AICAR at 48 h to 50%, 53%, and 46% of the control, respectively.

體內(nèi)研究

Fourteen-week-old male, lean (L; 31.3 g body wt) wild-type andob/ob (O; 59.6 g body wt) mice are injected with the AMP-activated kinase (AMPK) activator AICAR (A) at 0.5 mg*g body wt -1 *day -1 or saline control (C) for 14 days. At 24 h after the last injection (including a 12-h fast), all mice are killed, and the plantar flexor complex muscle (gastrocnemius, soleus, and plantaris) is excised for analysis. Muscle mass is lower in OC (159±12 mg) than LC, LA, and OA (176±10, 178±9, and 166±16 mg, respectively) mice, independent of a body weight change. The kidney weight is significantly higher in the untreated group when compared with both the exercise and AICAR (0.5 mg/g body wt) groups. The heart weight is higher in the exercise group than in the other groups, whereas the liver weight is significantly higher in the AICAR-treated group when compared with the exercise and untreated groups.

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