68-88-2
中文名稱
2-[2-[4-[(4-氯苯基)-苯甲基]哌嗪-1-基]乙氧基]乙醇
英文名稱
Hydroxyzine
CAS
68-88-2
分子式
C21H27ClN2O2
MDL 編號
MFCD00242772
分子量
374.904
MOL 文件
68-88-2.mol
68-88-2 結(jié)構(gòu)式
基本信息
中文別名
羥嗪2-[2-[4-[(4-氯苯基)-苯甲基]哌嗪-1-基]乙氧基]乙醇
英文別名
1-(p-Chloro-alpha-phenylbenzyl)-4-(2-((2-hydroxyethoxy)ethyl)piperazine1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine
1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
1-(p-Chlorodiphenylmethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol
2-(2-(4-[(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl)ethoxy)ethanol
Atara
Atarax
Atarax base
Ataraxoid
Atarazoid
Atarox
Atazina
Aterax
Deinait
Equipoise
Ethanol, 2-[2-[4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl]ethoxy]-
Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
Hychotine
Hydroksyzyny
所屬類別
原料藥：抗焦慮藥物理化學(xué)性質(zhì)
熔點(diǎn)190°C
沸點(diǎn)250 °C(Press: 0.1 Torr)
密度1.1020 (rough estimate)
折射率1.5400 (estimate)
儲存條件Sealed in dry,2-8°C
溶解度可溶于氯仿（少量）、DMSO（少量）、乙醇（少量）、甲醇（少量）
酸度系數(shù)(pKa)pKa 1.96± 0.05；7.40± 0.03(H2O,t =24.5±0.5)(Approximate)
形態(tài)油狀至凝膠狀
顏色無色至黃色
水溶解性< 700 mg/mL
BCS Class2
NIST化學(xué)物質(zhì)信息Hydroxyzine base(68-88-2)
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H334-H372-H360-H336-H302
毒害物質(zhì)數(shù)據(jù)68-88-2(Hazardous Substances Data)
毒性LD50 oral in rat: 840mg/kg
常見問題列表
生物活性
Hydroxyzine，一種苯二氮卓抗組胺劑 (antihistamine)，作為口服活性組胺 H1 受體 (histamine?H1-receptor) 和血清素拮抗劑。Hydroxyzine 具有抗焦慮作用，可用于廣泛性焦慮障礙的研究。靶點(diǎn)
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H 1 Receptor
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體外研究
Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.
體內(nèi)研究
Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.