67776-06-1
中文名稱(chēng)
N-乙?；?3-(硫代亞硝基)-DL-纈氨酸
英文名稱(chēng)
2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid
CAS
67776-06-1
分子式
C7H12N2O4S
MDL 編號(hào)
MFCD00272624
分子量
220.25
MOL 文件
67776-06-1.mol
更新日期
2024/11/18 14:11:53
67776-06-1 結(jié)構(gòu)式
基本信息
中文別名
S-亞硝基-N-乙酰-DL-青霉胺S-亞硝基N-乙?；?DL-青霉胺
N-乙?；?3-(亞硝基硫代)-纈氨酸
N-乙?；?3-(硫代亞硝基)-DL-纈氨酸
S-亞硝基-N-乙酰基-DL-青霉胺(SNAP)
英文別名
SNAP 所屬類(lèi)別
生物化工：纈氨酸類(lèi)衍生物物理化學(xué)性質(zhì)
熔點(diǎn)150.5°C
密度1.4261 (rough estimate)
RTECS號(hào)YV9383000
折射率1.5400 (estimate)
儲(chǔ)存條件−20°C
溶解度H2O: ≥2 mg/mL
酸度系數(shù)(pKa)3.06±0.10(Predicted)
形態(tài)powder
形態(tài)粉末
顏色green
顏色綠色
CAS 數(shù)據(jù)庫(kù)67776-06-1(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H315-H319-H335
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類(lèi)別碼R36/37/38
安全說(shuō)明S26-S36
WGK Germany3
常見(jiàn)問(wèn)題列表
生物活性
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) 是一種一氧化氮供體，是一種穩(wěn)定的血小板聚集抑制劑。體外研究
S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces toxicity of about 80% after 6 hours under normoxic conditions by releasing nitric oxide (NO).
S-Nitroso-N-acetyl-DL-penicillamine has a half-time about 6 hours in in isolated rat ventricular myocytes.
S-Nitroso-N-acetyl-DL-penicillamine (100 μM; 30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes.
Cell Viability Assay
| Cell Line: | Rat liver sinusoidal endothelial cells |
| Concentration: | 2 mM, 5 mM, 10 mM |
| Incubation Time: | 2 hours, 4 hours, 6 hours, 8 hours |
| Result: | Exhibited cytotoxicity against cultivated endothelial cells. |
體內(nèi)研究
SNAP (100μM, 300μM) causes small but significant increases of the electrically evoked [
3
H]-acetylcholine release in guinea-pig tracheal.