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6681-15-8

中文名稱 鹽酸藥根堿
英文名稱 JATRORRHIZINE HCL(RG)
CAS 6681-15-8
分子式 C20H20NO4.ClH
分子量 374.842
MOL 文件 6681-15-8.mol
更新日期 2025/01/07 18:54:22
6681-15-8 結構式 6681-15-8 結構式

基本信息

中文別名
酸鹽藥根堿
鹽酸藥根堿
藥根堿鹽酸鹽
鹽酸藥根堿(標準品)
鹽酸藥根堿(藥根堿鹽酸鹽)
鹽酸藥根堿, 來源于十大功勞
英文別名
Nsc150445
Neprotine chloride
Yatrorhizine chloride
JATRORRHIZINE HCL(RG)
Jatrochizine chloride
Jatorrhizine, chloride
(960383-96-4) jatrorrhizine hydrochloride
Jatrorrhizine,Neprotine chloride,Yatrorhizine chloride
Jatrorrhizine hydrochloride, 98%, from Mahonia fortunei (Lindl.) Fedde
所屬類別
生物化工:提取物

物理化學性質

熔點208-210 °C(Solv: methanol (67-56-1))
儲存條件Inert atmosphere,Room Temperature
溶解度Soluble in chloroform and methan
形態(tài)粉末
顏色橙紅色
穩(wěn)定性吸濕性

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302
防范說明P301+P312+P330
海關編碼29399990
鹽酸藥根堿價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08S9069鹽酸藥根堿
Jatrorrhizine chloride
6681-15-81mg876.72元
2023/01/06XW66811581鹽酸藥根堿
jatrorrhizine hydrochloride;jatrorrhizine chloride;neprotine chloride;2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol chloride
6681-15-820MG388元

常見問題列表

生物活性
Jatrorrhizine?chloride 是從黃連中分離得到的生物堿,具有神經(jīng)保護、抗菌、抗瘧原蟲和抗氧化活性。Jatrorrhizine?chloride 是有效的,具有口服活性的乙酰膽堿酯酶 (AChE) (IC50=872 nM) 的抑制劑,是對 BuChE 的選擇性為 115 倍。Jatrorrhizine?chloride 通過抑制 uptake-2 transporter 的活性減少血清素 (5-HT) 和去甲腎上腺素 (NE) 的攝取。
靶點
TargetValue
AChE
()
872 nM
體外研究

Jatrorrhizine has antiplasmodial and antiamoebic activity, it against Plasmodium falciparum and E. histolytica with IC 50 values of 3.15 and 82.7 μM, respectively.The hOCT2 (organic cation transporter 2), hOCT3, and PMAT (plasma membrane monoamine transporter) are capable of transporting monoamine neurotransmitters in the brain. Jatrorrhizine has the inhibitory potency of jatrorrhizine on 5-HT and NE uptake in hOCT2-, hOCT3-, and PMAT-transfected cells. Jatrorrhizine strongly inhibits PMAT-mediated MPP + uptake with an IC 50 value of 1.05 μM and reduces 5-HT and NE uptake mediated by hOCT2, hOCT3, and hPMAT with IC 50 values of 0.1-1 μM (for OCT2 and OCT3) and 1-10 μM (for PMAT).Clearance of neurotransmitters released into the synaptic cleft is defined by two distinct processes. Uptake-1, the common target of current applied antidepressants, is comprised of the serotonin transporter (SERT), the “SERT”, had a high affinity but low capacity to take up [3H]5-HT. Uptake-2 transporters are an important supplementary regulation system in monoamine clearancethought to be the “NET”, has low affinity but high capacity to take up [ 3 H]5-HT into brain slices. Jatrorrhizine significantly inhibited 5-HT and NE uptake in synaptosomes at 25 μM and 50 μM.

體內研究

Jatrorrhizine chloride (intraperitoneal?injection; 5, 10, 20 mg/kg) can significantly reduce the duration of immobility when compared with vehicle control group in tail suspension test (TST).

Animal Model: Male ICR albino mice
Dosage: 5, 10, 20 mg/kg
Administration: Intraperitoneal?injection; 5, 10, 20 mg/kg
Result: Reduced immobility period in tail suspension test.
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