664338-39-0
664338-39-0 結(jié)構(gòu)式
基本信息
中文別名
青蒿氧烷 英文別名
OZ 277Arterolane
RBx 11160)
Arterolane (OZ277
-[1,2,4]trioxolane-5&rsquo
-tricyclo[3.3.1.13,7]decane]-4-acetamide
cis-N-(2-Amino-2-methylpropyl)dispiro[cyclohexane-1,3&rsquo
Dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.13,7]decane]-4-acetamide, N-(2-amino-2-methylpropyl)-, cis-
物理化學(xué)性質(zhì)
熔點(diǎn)160-162℃
沸點(diǎn)572.2±45.0 °C(Predicted)
密度1.20
儲(chǔ)存條件Store at -20°C, protect from light, stored under nitrogen
溶解度可溶于DMSO
酸度系數(shù)(pKa)16.70±0.46(Predicted)
形態(tài)固體
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
Arterolane 是一種抗瘧疾劑，對(duì) P. falciparum Ro73 和 W2 的 IC50 值均為 1.1 nM。靶點(diǎn)
IC50: 1.1 nM ( P. falciparum Ro73), 1.1 nM ( P. falciparum W2)
體外研究
Arterolane (Trioxolane 7; OZ277; RBx-11160) is an antimalarial agent, with IC 50 s of both 1.1 nM (0.43 ng/mL) against P. falciparum Ro73 and W2, respectively. Arterolane also shows inhibitory activity against several other P. falciparum s, with IC 50 s of 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, and 0.84 ng/mL for P. falciparum K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20, respectively.