645-43-2
中文名稱
單硫酸胍乙啶
英文名稱
GUANETHIDINE SULFATE
CAS
645-43-2
EINECS 編號
211-442-0
分子式
C10H24N4O4S
MDL 編號
MFCD00035403
分子量
296.39
MOL 文件
645-43-2.mol
更新日期
2025/01/28 09:37:41
645-43-2 結構式
基本信息
中文別名
單硫酸胍乙啶硫酸胍乙啶
英文別名
GUANETHIDINE MONOSULFATEGUANETHIDINE MONOSULFATE (1:1)
GUANETHIDINE SULFATE
(2-(hexahydro-1(2h)-azocinyl)ethyl)guanidinehydrogensulfate
(2-(hexahydro-1(2h)-azocinyl)ethyl)-guanidinsulfate(1:1)
2-(octahydro-1-azocinyl)ethylguanidinesulphate
n-(2-guanidinoethyl)heptamethyleniminesulfate
Guanethidine Sulphae
[2-(hexahydro-(2H)-azocin-1-yl)ethyl]guanidinium sulphate
GUANETHIDINEMONOSULFATE,USP
1-(2-Guanidinoethyl)octahydroazocine
2-(1-Azacyclooctyl)ethylguanidine monosulfate
所屬類別
原料藥：抗高血壓病藥物理化學性質
熔點276-281 °C
儲存條件2-8°C
溶解度易溶于水，幾乎不溶于乙醇（96%）
形態(tài)固體
顏色白色至灰白色
穩(wěn)定性吸濕性
InChIKeyYUFWAVFNITUSHI-UHFFFAOYSA-N
應用領域
用途1
為腎上腺.素能神經阻斷劑。其作用是干擾交感神經末梢去甲腎上腺.素的釋放，亦耗竭去甲腎上腺.素的貯存，因而當腎上腺.素能神經沖動達到末梢時，不再有足量的介質進行傳遞，交感神經活動降低，血壓下降，其降壓作用較強而持久。主要用于中度和重度舒張壓高的高血壓、較頑固的高血壓及腎性高血壓等。單硫酸胍乙啶價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-B0800 | 單硫酸胍乙啶 Guanethidine sulfate | 645-43-2 | 100mg | 500元 |
| 2024/11/08 | HY-B0800 | 單硫酸胍乙啶 Guanethidine sulfate | 645-43-2 | 10mM * 1mLin Water | 550元 |
| 2024/11/08 | HY-B0800 | 單硫酸胍乙啶 Guanethidine sulfate | 645-43-2 | 500 mg | 1000元 |
常見問題列表
生物活性
Guanethidine sulfate (Guanethidine monosulfate) 是一種抗高血壓藥。Guanethidine sulfate 也是一種腎上腺素能神經元阻滯藥，通過神經元胺載體進入去甲腎上腺素能神經末梢。體內研究
Guanethidine (5-40 mg/kg; intraperitoneal injection; daily; for 4-28 days; male Wistar rats) treatment for 28 days by 40 mg/kg results in an incomplete sympathectomy accompanied by a partially irreversible hypersensitivity to noradrenaline, whereas 5 mg/kg does not induce histological or permanent haemodynamic changes.
| Animal Model: | Male Wistar rats (approximately 200 g) |
| Dosage: | 5 mg/kg or 40 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 4, 8, 14, or 28 days |
| Result: | Lowered the blood pressure by 40 mg/kg, the decrease being reversible on discontinuation. The hypersensitivity was partly reversible on discontinuation, but a significantly increased sensitivity of the heart rate to noradrenaline was observed 60 days after discontinuation by 40 mg/kg for 28 days. Histologically a profound loss of nerve cells of the superior cervical ganglion was observed by 40 mg/kg. |