642-15-9
642-15-9 結(jié)構(gòu)式
基本信息
中文別名
抗霉素A1二氫沙米丁
二氫沙米汀
抗黴素A1
抗黴素A1,二氫沙米丁
英文別名
ANTIMYCIN A1dihydrosamidin
1,5-Dioxonane butanoic acid deriv.
-dioxo-1,5-dioxonan-3-yl)salicylamide
isovalericacid,8-esterwith3-formamido-n-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6
3-(3-formamidosalicylamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl isovalerate
[3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
[3-[(3-formamido-2-hydroxy-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
3-methylbutyric acid [3-[(3-formamido-2-hydroxy-benzoyl)amino]-8-hexyl-4,9-diketo-2,6-dimethyl-1,5-dioxonan-7-yl] ester
3-Methylbutyric acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
所屬類別
生物化學(xué)品: 生化試劑: 實驗室通用藥物物理化學(xué)性質(zhì)
外觀性狀白色結(jié)晶。不溶于水，溶于乙醇，易溶于丙酮和氯仿。Mp149-150℃ (A1)，170-171.5℃(A3)；A1在乙醇中最大吸收波長為226nm和320nm，A3在甲醇中最大吸收波長是225nm和320nm；A1的比旋光度[α]26D+76°(1%，氯仿)，A3為+64.3°(氯仿)。低毒，LD50(大鼠，經(jīng)口)1469mg/kg(A1)。
熔點149.5℃
比旋光度D26 +76° (c = 1 in chloroform)
沸點620.81°C (rough estimate)
密度1.2468 (rough estimate)
折射率1.5800 (estimate)
儲存條件−20°C
溶解度DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
形態(tài)固體
安全數(shù)據(jù)
警示詞危險
危險性描述H301-H311-H331
危險品標(biāo)志T
危險類別碼23/24/25
安全說明36/37/39-45
危險品運輸編號3172
RTECS號NY1503500
危險等級6.1(a)
包裝類別II
抗黴素A1價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2022/09/18 | HY-107406 | 抗黴素A1 Antimycin A1 | 642-15-9 | 500μg | 5600元 |
| 2022/09/18 | HY-107406 | 抗黴素A1 Antimycin A1 | 642-15-9 | 1mg | 9600元 |
常見問題列表
生物活性
Antimycin A1 是泛醇-細(xì)胞色素 c 氧化還原酶的特定電子轉(zhuǎn)移 (electron transfer) 抑制劑。Antimycin A1 通過抑制 HIF-1α 激活導(dǎo)致的 VEGF 產(chǎn)生減少來抑制血管生成。體外研究
Antimycin A, a mixture of Antimycins A1, A2, A3, and A4, is an antibiotic produced by Streptomyces species and displays antifungal, insecticidal, nematocidal, and piscicidal properties. Antimycin A inhibits Bcl-2 and Bcl-xL proteins, inducing apoptosis.