63701-55-3
中文名稱
R(+)-巴氯芬鹽酸鹽
英文名稱
R(+)-Baclofen.Hydrochloride
CAS
63701-55-3
分子式
C10H13Cl2NO2
分子量
250.12
MOL 文件
63701-55-3.mol
63701-55-3 結(jié)構(gòu)式
基本信息
中文別名
R(+)-巴氯芬鹽酸鹽 英文別名
R(+)-BACLOFEN HCLSTX-209 HYDROCHLORIDE
d-baclofenhydrochloride
Arbaclofen hydrochloride
R(+)-BACLOFEN HYDROCHLORIDE
(+)-Baclofen (hydrochloride)
(r)-baclofenmonohydrochloride
Arbaclofen hydrochloride salt
Baclofen (R)-(+)- hydrochloride
R(+)-BACLOFENHYDROCHLORIDE(FORR&DONLY)
物理化學(xué)性質(zhì)
熔點(diǎn)220～222℃
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: >20 mg/mL
形態(tài)solid
顏色white
旋光性 (optical activity)[α]28/D +3.8°, c = 0.9 in methanol(lit.)
常見(jiàn)問(wèn)題列表
生物活性
(R)-Baclofen hydrochloride (STX 209 hydrochloride) 是選擇性 GABAB 受體激動(dòng)劑。靶點(diǎn)
GABAB receptor
體內(nèi)研究
(R)-Baclofen hydrochloride (STX 209 hydrochloride) suppresses audiogenic seizures in the
Fmr1
-knockout mouse on the seizure-resistant C57BL/6 background with an effective dose of 1 mg/kg.
Acute intraperitoneal administration of (R)-Baclofen hydrochloride significantly reduces the percent of mice displaying seizures (seizure incidence), with a minimum effective dose (MED) of 1.5 mg/kg.