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6104-71-8

中文名稱 8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃
英文名稱 N-DESMETHYLCLOZAPINE
CAS 6104-71-8
分子式 C17H17ClN4
MDL 編號(hào) MFCD00210189
分子量 312.8
MOL 文件 6104-71-8.mol
更新日期 2024/12/23 13:18:49
6104-71-8 結(jié)構(gòu)式 6104-71-8 結(jié)構(gòu)式

基本信息

中文別名
去甲氯氮平
N-去甲氯氮平
氯氮平EP雜質(zhì)C
N-去甲基氯氮平
N-去甲基氣氮平
氯羥喹雜質(zhì)C(EP)
氯氮平雜質(zhì)C(EP)
去甲氯氮平溶液,100PPM
8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]吡喃
8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]二氮雜卓
英文別名
N-DESMETHYLCLOZAPINE
所屬類別
分析化學(xué):標(biāo)準(zhǔn)物質(zhì)

物理化學(xué)性質(zhì)

熔點(diǎn)120-125°C
沸點(diǎn)502.6±60.0 °C(Predicted)
密度1.38±0.1 g/cm3(Predicted)
閃點(diǎn)9℃
儲(chǔ)存條件Store at RT
溶解度可溶于氯仿(少許)、DMSO、甲醇(少許)
酸度系數(shù)(pKa)8.49±0.10(Predicted)
形態(tài)黃色固體
顏色淡黃色至黃色
CAS 數(shù)據(jù)庫6104-71-8(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302+H332-H315-H319-H335
危險(xiǎn)品標(biāo)志Xn,T,F
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼R20/22-R36/37/38
安全說明S22-S36-S45
危險(xiǎn)品運(yùn)輸編號(hào)3249
WGK Germany3
WGK Germany3
危險(xiǎn)等級(jí)6.1(b)
包裝類別III

知名試劑公司產(chǎn)品信息

常見問題列表

生物活性
N-Desmethylclozapine 是非典型抗精神病藥 Clozapine 的主要活性代謝產(chǎn)物。N-Desmethylclozapine 是一種有效的、變構(gòu)的部分 M1 受體激動(dòng)劑 (EC50=115 nM),能通過 M1 受體激活增強(qiáng)海馬 N-methyl-d-aspartate (NMDA) 受體電流。N-Desmethylclozapine 也是 δ-opioid 激動(dòng)劑。
靶點(diǎn)

EC50: 115 nM (M1 receptors)
δ-opioid

體外研究

The brain penetrant metabolite N-desmethylclozapine preferentially bound to M1 muscarinic receptors with an IC 50 of 55 nM and was a more potent partial agonist (EC 50 , 115 nM and 50% of acetylcholine response) at this receptor than clozapine.
N-desmethylclozapine exhibits slight agonistic effects on the M1 mAChR, and agonistic properties at the 5-HT1A receptor in the cerebral cortex and hippocampus. This compound also behaves as an agonist at the δ-opioid receptor in the cerebral cortex and striatum.
N-desmethylclozapine (3 μM) greatly decreases the outward current in excitatory neurons, but not in inhibitory neurons. In excitatory neurons, N-desmethylclozapine alone is more effective than either clozapine alone or the combination of clozapine and N-desmethylclozapine. The effect of N-desmethylclozapine in excitatory neurons is significantly suppressed by 0.1 μM pirenzepine and 1 μM atropine. N-desmethylclozapine, but not clozapine, suppressed K + channels via M1 receptors in excitatory cells.
N-desmethylclozapine leads to a decrease in TxB2 levels under unstimulated conditions as well as under TSST-1 stimulation. Clozapine, N-desmethylclozapine and CPZ possibly act on neurotransmitter systems via modulation of TxA2 or TxB2 production.
The IC 50 s of N-desmethylclozapine, fluoxetine hydrochloride, and salmeterol xinafoate in Huh-7 cells infected with DENV-2 are 1 μM, 0.38 μM, and 0.67 μM, respectively. The levels of NS3 are reduced in cells treated with all three inhibitors compared to DMSO treatment, suggesting that the inhibitors act at a stage prior to viral protein translation. N-Desmethylclozapine-treated cells show a >75% reduction in negative-strand RNA levels.

體內(nèi)研究

N-desmethylclozapine in rat and human at M2 and M4 mAChRs underlying presynaptic modulation of GABA and glutamate release, respectively. In particular, N-desmethylclozapine maybe a M2 mAChR antagonist in the rat but has no activity at this receptor in human neocortex. However, N-desmethylclozapine has an agonistic effect at M4 mAChR in the human but no such effect in the rat neocortex.

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