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56776-01-3

中文名稱 鹽酸妥布特羅
英文名稱 Tulobuterol hydrochloride
CAS 56776-01-3
分子式 C12H19Cl2NO
MDL 編號 MFCD00214398
分子量 264.19
MOL 文件 56776-01-3.mol
更新日期 2024/12/25 08:44:53
56776-01-3 結構式 56776-01-3 結構式

基本信息

中文別名
(+/-)-2-氯-2-[(叔丁基氨基)甲基]苯甲醇鹽酸鹽
鹽酸妥布特羅
鹽酸妥洛特羅
鹽酸妥布托羅
鹽酸妥布特
(+/-)-2-氯-2-[(叔丁基氨基)甲基]苯甲醇鹽酸鹽
英文別名
alpha-[(tert-butylamino)methyl]-o-chlorobenzyl alcohol hydrochloride
TULOBUTEROL HCL
TULOBUTEROL HYDROCHLORIDE
1-(o-chlorophenyl)-2-tert-butylaminoethanolhydrochloride
2-chloro-alpha-(((1,1-dimethylethyl)amino)methyl)-benzenemethanohydrochl
alpha-((tert-butylamino)methyl)-o-chloro-benzylalcohohydrochloride
alpha-(tert-butylamino)methyl-2-chloro-benzylalcohohydrochloride
alpha-(tert-butylamino)methyl-2-chlorobenzylalcoholhydrochloride
c78
chlobamolhydrochloride
lobuterol
o-chloro-alpha-((tert-butylamino)methyl)benzylalcoholhydrochloride
TULOBUTEROL HG 99%
TULOBUTEROL HG
Atenos
Benzenemethanol, 2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-, hydrochloride (9CI)
Berachin
Brelomax
Bremax
Chlibamol
所屬類別
原料藥:平喘藥

物理化學性質(zhì)

熔點159-163℃
儲存條件2-8°C
溶解度可溶于DMSO(少許)、甲醇(少許)
形態(tài)neat
顏色白色
水溶解性Soluble in methanol or water.
敏感性吸濕性
Merck14,9811
InChIKeyRSLNRVYIRDVHLY-UHFFFAOYSA-N
CAS 數(shù)據(jù)庫56776-01-3(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302
危險品標志Xn
危險類別碼R22
WGK Germany3
RTECS號DN8785000
海關編碼2922.19.7000

56776-01-3(安全特性,毒性,儲運)

儲運特性
庫房通風低溫干燥; 與食品原料類分開存放
毒性分級
高毒
急性毒性
口服-大鼠 LD50: 560 毫克/公斤; 口服-小鼠 LD50: 243 毫克/公斤
可燃性危險特性
熱分解排出有毒氮氧化物, 氯化物氣體
類別
有毒物質(zhì)
滅火劑
水,干粉、干砂、二氧化碳、泡沫、1211滅火劑

知名試劑公司產(chǎn)品信息

常見問題列表

生物活性
Tulobuterol是長效的β2-adrenergic receptor激動劑,具有支氣管擴張、消炎和抗病毒活性。
靶點

β2-adrenoceptor

體外研究

Tulobuterol (0.1 μM; 24 hours or 72 hours; human tracheal epithelial cells) treatment decreases the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells treated with tulobutero are significantly lower than those in the cells treated with vehicle before RV14 infection. Treatment with tulobuterol reduces the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduces the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. Tulobuterol treatment produces a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.

RT-PCR

Cell Line: Human tracheal epithelial cells infected with RV14
Concentration: 0.1 μM
Incubation Time: 24 hours or 72 hours
Result: Decreased the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells were significantly lower. Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduced the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. And produced a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.
體內(nèi)研究

In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E. coli endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h.

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