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555-60-2

中文名稱 羰基氰化氯苯腙
英文名稱 CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
CAS 555-60-2
EINECS 編號(hào) 209-103-7
分子式 C9H5ClN4
MDL 編號(hào) MFCD00001848
分子量 204.62
MOL 文件 555-60-2.mol
更新日期 2024/10/25 11:10:53
555-60-2 結(jié)構(gòu)式 555-60-2 結(jié)構(gòu)式

基本信息

中文別名
羰基氰化氯苯腙
羰基氰基3-氯苯腙
氰化羰基-3-氯苯腙
氰化羰基間氯苯腙
羰基氰酯-3-氯苯基腙
羰基氰基3-氯苯腙/羰基氰化氯苯腙/CCCP
英文別名
[(3-CHLOROPHENYL)HYDRAZONO]PROPANEDINITRILE
BUTTPARK 91\04-41
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
CARBONYL CYANIDE M-CHLOROPHENYL-HYDRAZONE
CCCP
M-CL-CCP
MESOXALONITRILE (3-CHLOROPHENYL)HYDRAZONE
TIMTEC-BB SBB003506
((3-chlorophenyl)hydrazono)-propanedinitril
[(3-chlorophenyl)hydrazono]-propanedinitril
m-chlorophenylcarbonylcyanidehydrazone
mesoxalonitrile,(m-chlorophenyl)hydrazone
[(3-chlorophenyl)hydrazono]malononitrile
CARBONYL CYANIDE M-CHLOROPHENYL &
Carbonylcyanide3-chlorophenylhydrazone,98%
Carbonyl cyanide 3-chlorophenylhydrazone, 99+%
Carbonylcyanid-m-chlorphenylhydrazon
m-Cl-CCP, Carbonyl cyanide 3-chlorophenylhydrazone, CCCP, Mesoxalonitrile (3-chlorophenyl)hydrazone, Mesoxalonitrile 3-chlorophenylhydrazone
m-Cl-CCP, CCCP, Mesoxalonitrile 3-chlorophenylhydrazone
Carbonyl cyanide m-chlorophenylhydrazone, 99+%
所屬類別
化學(xué)試劑:腙

物理化學(xué)性質(zhì)

熔點(diǎn)170-175 °C (dec.)
熔點(diǎn)170-175 °C (dec.)
沸點(diǎn)333.84°C (rough estimate)
密度1.3807 (rough estimate)
折射率1.6110 (estimate)
儲(chǔ)存條件-20°C
儲(chǔ)存條件2-8°C
溶解度methanol: 10 mg/mL, clear, very deep yellow
溶解度甲醇:10 mg/mL,澄清,深的黃色
酸度系數(shù)(pKa)6.00±0.10(Predicted)
形態(tài)powder
形態(tài)粉末
顏色yellow to orange
顏色黃色到橙色
水溶解性Insoluble in water. Soluble in DMSO (5 mg/ml), ethanol (1 mg/ml) and methanol (10 mg/ml).
BRN1842102
暴露限值NIOSH: IDLH 25 mg/m3
InChIKeyUGTJLJZQQFGTJD-UHFFFAOYSA-N
CAS 數(shù)據(jù)庫555-60-2(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H301+H311+H331-H315-H319-H335
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼23/24/25-36/37/38
危險(xiǎn)類別碼R23/24/25-R36/37/38
安全說明26-36/37-45
安全說明S26-S36/37-S45
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 3
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 3
WGK Germany3
WGK Germany3
RTECS號(hào)FG5600000
TSCAYes
危險(xiǎn)等級(jí)6.1
包裝類別III
海關(guān)編碼29280090
羰基氰化氯苯腙價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19L06932羰基氰酯-3-氯苯基腙, 98%
Carbonyl cyanide 3-chlorophenylhydrazone, 98%
555-60-2100mg239元
2024/08/19L06932羰基氰酯-3-氯苯基腙, 98%
Carbonyl cyanide 3-chlorophenylhydrazone, 98%
555-60-2500mg706元
2024/08/1922813羰基氰化氯苯腙
Carbonyl cyanide 3-chlorophenylhydrazone, 98%, Thermo Scientific Chemicals
555-60-2100mg518元

常見問題列表

生物活性
CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone)是一種氧化磷酸化抑制劑,是線粒體質(zhì)子載體解偶聯(lián)劑,可增加線粒體膜對(duì)質(zhì)子的通透性,從而破壞線粒體膜電位。
靶點(diǎn)

STING
IFN-β

體外研究

CCCP inhibits IFN-β production induced by various types of the STING pathway activators. CCCP suppresses the phosphorylation of STING, TBK1, and IRF3 via disrupting the association of STING and TBK1. CCCP inhibits activation of STING and its downstream signaling molecules, TBK1 and IRF3, but not STING translocation to the perinuclear region. CCCP impairs the interaction between STING and TBK1 and concomitantly triggers mitochondria fission. Importantly, the knockout of the crucial mitochondria fission regulator Drp1 restored the STING activity, indicating that CCCP down-modulates the STING pathway through DRP1-mediated mitochondria fragmentation. The protonophore CCCP that disrupts membrane potential suppresses the DMXAA-triggered STING signaling pathway. CCCP drastically suppresses the production of IFN-β in DMXAA-treated RAW264.7 cells and MEFs.

體內(nèi)研究

The same dosage of 3?mg/kg.bw each of CCCP and PPEF is used. In both the cases 1?log reduction is observed in the bacterial load. However, when 3?mg/kg.bw of PPEF is used in combination with 3?mg/kg.bw of CCCP, 6 log 10 reduction is observed in the bacterial count. The developed model validates the enhanced antibacterial activity of combination therapy. 99m Tc-MIBI signals in the hearts of SD rats administered CCCP (4 mg/kg intraperitoneally) or vehicle is also measured. 99m Tc-MIBI signals decrease in rat hearts administered CCCP, and the ATP content, as measured by 31 P magnetic resonance spectroscopy, decreased simultaneously. To investigate whether CCCP decreased the 99m Tc-MIBI signals in rats, we analyzed the radioisotope activity of excised heart tissue from rats administered CCCP. At 180 min after 99m Tc-MIBI injection, the 99m Tc-MIBI signals from the hearts in the CCCP group are significantly lower than those in the vehicle group.

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