5119-48-2
基本信息
醉茄素 A,來源于睡茄葉
WITHAFERIN A STANDARD
nsc-101088
Withaferine
WITHAFERIN A
withaferinea
Withaferin A Standard
Withaferin A 5119-48-2
delta-lactone,(20s,22r)-oxo
Withaferin A from leaves of Withania somnifera
5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
2024/11/08 | S8587 | 醉茄素 A Withaferin A | 5119-48-2 | 1mg | 1470.11元 |
2024/11/08 | S8587 | 醉茄素 A Withaferin A | 5119-48-2 | 5mg | 4290.34元 |
2024/11/08 | HY-N2065 | 醉茄素 A Withaferin A | 5119-48-2 | 1mg | 1300元 |
常見問題列表
Target | Value |
NF-κB
() | |
vimentin
() |
Withaferin A has antiinflammatory activity, and potently inhibits NF-kB activation by preventing the TNF-induced activation of Ik-B kinase beta via a thioalkylation-sensitive redox mechanism. Withaferin A also has anticancer activity. Withaferin A targets the IF protein vimentin, causes aggregation of vimentin filaments in bovine aortic endothelial cells (BAECs) at 3 μM, and induces vimentin fragmentation in endothelial cells at 10 μM. Withaferin A (0.5, 1.5 μM) alone or incombination with cisplatin (CIS) dose-dependently reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs).
Withaferin A (2 mg/kg, i.p.) shows potent angiogenesis inhibitory activity via vimentin in mice. Withaferin A (2 mg/kg) combined with cisplatin (CIS) regulates the expression of ALDH1 marker, and downregulates the expression of securin in tumors collected from mice.