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51-98-9

中文名稱 炔諾酮醋酸酯
英文名稱 19-Norethindrone acetate
CAS 51-98-9
EINECS 編號 200-132-0
分子式 C22H28O3
MDL 編號 MFCD04039850
分子量 340.46
MOL 文件 51-98-9.mol
更新日期 2024/12/20 09:16:38
51-98-9 結(jié)構(gòu)式 51-98-9 結(jié)構(gòu)式

基本信息

中文別名
醋酸炔諾酮
炔諾酮醋酸酯
17β-羥基9-去甲-17α-孕甾-4-烯-20-炔-3-酮-17-醋酸酯
17Α-乙炔基-17Β-羥基雌甾-4-烯-3-酮17-醋酸酯
17Α-乙炔基雌甾-4-烯-17Β-醇-3-酮17-醋酸酯
17Β-乙酰氧基-17Α-乙炔基雌甾-4-烯-3-酮
英文別名
17a-ethynyl-19-nortestosterone 17b-acetate
17ALPHA-ETHYNYL-17BETA-HYDROXY-19-NOR-4-ANDROSTEN-3-ONE 17-ACETATE
17ALPHA-ETHYNYL-19-NORTESTOSTERONE 17BETA-ACETATE
17ALPHA-ETHYNYL-19-NORTESTOSTERONE ACETATE
17-hydroxy-19-nor-17a-4-pregnen-20-yn-3-one acetate
17-HYDROXY-19-NOR-17ALPHA-4-PREGNEN-20-YN-3-ONE ACETATE
19-NOR-17ALPHA-ETHYNYLTESTOSTERONE ACETATE
19-NORESTHISTERONE ACETATE
19-NORETHINDRONE ACETATE
19-NORETHISTERONE 17-ACETATE
19-NORETHISTERONE ACETATE
4-ESTREN-17ALPHA-ETHYNYL-17BETA-OL-3-ONE 17-ACETATE
4-ESTREN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE ACETATE
ACETIC ACID 17-ETHYNYL-13-METHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPE
NORETHINDRONE ACETATE
NORETHISTERONE ACETATE
(17-alpha)-17-(Acetyloxy)-19-norpregn-4-en-20-yn-3-one
(17α)-17-(acetyloxy)-19-norpregn-4-en-20-yn-3-one
17-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-on
17-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one
所屬類別
有機(jī)原料:羧酸酯及其衍生物

物理化學(xué)性質(zhì)

熔點(diǎn)161-162°
沸點(diǎn)416.25°C (rough estimate)
密度1.1236 (rough estimate)
折射率-34 ° (C=1, Dioxane)
儲存條件2-8°C
溶解度幾乎不溶于水,易溶于二氯甲烷,溶于乙醇。
形態(tài)neat
顏色Crystals from Me2CO/hexane
水溶解性3.162mg/L(10 ºC)
Merck6697
InChIKeyIMONTRJLAWHYGT-ZCPXKWAGSA-N
CAS 數(shù)據(jù)庫51-98-9(CAS DataBase Reference)
NIST化學(xué)物質(zhì)信息Norethindrone acetate(51-98-9)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS08
警示詞警告
危險性描述H351
危險品標(biāo)志Xn
危險類別碼R40-R48
安全說明S36/37
WGK Germany3
RTECS號RC8965000
海關(guān)編碼29372390
毒性dlt-mus-orl 1120 mg/kg/4W MUREAV 26,535,74

應(yīng)用領(lǐng)域

用途一
孕激素類藥,用于月經(jīng)不調(diào)、子宮功能性出血、子宮內(nèi)膜異位癥等。

常見問題列表

簡介
炔諾酮醋酸酯是一種雌性激素,可用作孕激素類藥,用于月經(jīng)不調(diào)、子宮功能性出血、子宮內(nèi)膜異位癥等。
禁忌

已知或疑有乳癌、雌激素依賴性腫瘤,有乳癌病史者,代謝性卟啉病患者。

生物活性
Norethindrone acetate 是一種雌性激素,可用于子宮內(nèi)膜異位癥研究。
靶點(diǎn)

Progesterone Receptor

體內(nèi)研究

Norethindrone acetate could be a cost-effective alternative with relatively mild side effects in the treatment of symptomatic endometriosis. Subjects treated with norethindrone acetate obtain dysmenorrhea and noncyclic pelvic pain relief. Norethindrone acetate alone is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis. Post-Norethindrone acetate bleeding scores are improved regardless of prior hormonal regimen, and post-Norethindrone acetate pain scores improved in all patients except for those previously prescribed GnRH-agonist plus add-back. Norethindrone acetate shows low acute toxicity in experimental animals and is consistent with the lack of toxicity seen in humans. Administration of norethindrone acetate alone to rodents at several multiples of the human dose results in no treatment related mortality, hematological changes, behavioral changes, or organ pathology. Norethindrone acetate administration leads to significant and proportional reductions of the concentrations of triglycerides, cholesterol and phospholipids of plasma lipoproteins of density <1.006 of rats fed a high carbohydrate diet. Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides of isolated hepatocytes from fed rats.

知名試劑公司產(chǎn)品信息

炔諾酮醋酸酯價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-B1710炔諾酮醋酸酯
Norethindrone acetate
51-98-9100mg300元
2024/11/08HY-B1710炔諾酮醋酸酯
Norethindrone acetate
51-98-910mM * 1mLin DMSO330元
2024/11/08N0450醋酸炔諾酮
Norethisterone Acetate
51-98-9100MG140元
"51-98-9" 相關(guān)產(chǎn)品信息
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