501698-03-9
501698-03-9 結構式
基本信息
中文別名
化合物GDP366化合物 T11383
1-(4-(4-氨基噻吩并[2,3-D]嘧啶-5-基)苯基)-3-(間甲苯基)脲
英文別名
GDP366GDP366
GDP-366
GDP 366
Urea, N-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N'-(3-methylphenyl)-
物理化學性質
熔點227-228 °C(Solv: ethanol (64-17-5))
沸點538.5±50.0 °C(Predicted)
密度1.423±0.06 g/cm3(Predicted)
儲存條件Keep in dark place,Sealed in dry,2-8°C
溶解度DMSO:62.5(Max Conc. mg/mL);166.47(Max Conc. mM)
酸度系數(pKa)14.22±0.70(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
501698-03-9價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-U00177 | GDP366 | 501698-03-9 | 1 mg | 2095元 |
| 2025/02/08 | HY-U00177 | 501698-03-9 GDP366 | 501698-03-9 | 5mg | 5500元 |
| 2025/02/08 | HY-U00177 | GDP366 | 501698-03-9 | 10 mM * 1 mLin DMSO | 6050元 |
常見問題列表
生物活性
GDP366 是 survivin 和 Op18 的雙重抑制劑，抑制癌細胞生長，誘導細胞衰老和有絲分裂突變。靶點
Survivin
Op18
體外研究
GDP366 potently and selectively inhibits the expression of both survivin and Op18. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 increases chromosomal instability, and induces cellular senescence by inhibiting telomerase activity.