| Identification | Back Directory | [Name]
GDP366 | [CAS]
501698-03-9 | [Synonyms]
GDP366
GDP366;GDP-366;GDP 366
Urea, N-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N'-(3-methylphenyl)- | [Molecular Formula]
C20H17N5OS | [MDL Number]
MFCD31544386 | [MOL File]
501698-03-9.mol | [Molecular Weight]
375.45 |
| Chemical Properties | Back Directory | [Melting point ]
227-228 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
538.5±50.0 °C(Predicted) | [density ]
1.423±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO:62.5(Max Conc. mg/mL);166.47(Max Conc. mM) | [form ]
Solid | [pka]
14.22±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. | [References]
[1] Shi X, et al. GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. Cancer Biol Ther. 2010 Apr 15;9(8):640-50. DOI:10.4161/cbt.9.8.11269 |
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