499-44-5
499-44-5 結構式
基本信息
檜木醇
日柏醇
Β-檜酚酮
Β-異丙【草(之上)+卓】酚酮
2-HYDROXY-4-ISOPROPYL-2,4,6-CYCLOHEPTATRIEN-1-ONE
2-HYDROXY-4-ISOPROPYL-2,4,6-CYCLOHEPTATRIENE
2-HYDROXY-4-ISOPROPYLCYCLOHEPTA-2,4,6-TRIEN-1-ONE
4-ISOPROPYLTROPOLONE
BETA-THUJAPLICIN
BETA-THUJAPLICINE
B-THUJAPLICIN
HINOKITIOL
2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-isopropyl-
6-cycloheptatrien-1-one,2-hydroxy-4-(1-methylethyl)-4
6-cycloheptatrien-1-one,2-hydroxy-4-isopropyl-4
beta-Isopropyltropolon
beta-Isopropyltropolone
Hinokitol
Thujaplicin, beta
Tropolone, 4-isopropyl-
2-hydroxy-4-isopropyl-2,4,6-cyclohepta-2,4,6-trien-1-one
2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)-
Isopropyltropolone
物理化學性質
常見問題列表
2，從香芹酮經(jīng)環(huán)氧化、縮醛化等六步反應合成檜木醇。
3，從異丙基環(huán)己酮或異丙基環(huán)己烯酮經(jīng)轉變成羥基腈，兩步制成異丙基環(huán)庚酮，再經(jīng)氧化、溴化、脫溴化氫制備。
4，溴代環(huán)庚三烯酮與一種有機物反應，然后催化氫化合成。
5，從環(huán)戊二烯與一個二氯烯酮加成制成異丙基環(huán)戊二烯，再進行溶劑解，經(jīng)三步反應合成檜木醇。
前四種制備方法合成路線步驟太多或原料難以得到，實際上無法工業(yè)生產(chǎn)。因此近年來主要集中在第五種合成方法的研究。
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DNMT1
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Nrf2
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In U87MG and T98G glioma cell lines, hinokitiol demonstrates a dose-dependent decrease in viability, with IC 50 values of 316.5 ± 35.5 and 152.5 ± 25.3 μM, respectively. Hinokitiol represses ALDH activity and self-renewal ability in glioma stem cells, and inhibits in vitro oncogenicity. Hinokitiol also reduces Nrf2 expression in glioma stem cells in a dose-dependent manner. Hinokitiol (0-100 μM) inhibits colon cancer cell growth in a dose- and time-dependent manner. Hinokitiol (5, 10 μM) decreases DNMT1 and UHRF1 mRNA and protein expression, and increases TET1 expression via enhancement of 5hmC level in HCT-116 cells. Furthermore, hinokitiol reduces methylation status and restores mRNA expression of MGMT , CHST10 , and BTG4 genes.
知名試劑公司產(chǎn)品信息
Hinokitiol,>99.0%(GC)(499-44-5)