490-78-8
中文名稱
2,5-二羥基苯乙酮
英文名稱
2',5'-Dihydroxyacetophenone
CAS
490-78-8
EINECS 編號(hào)
207-716-4
分子式
C8H8O3
MDL 編號(hào)
MFCD00002343
分子量
152.15
MOL 文件
490-78-8.mol
更新日期
2024/12/17 10:21:12
490-78-8 結(jié)構(gòu)式
基本信息
中文別名
2,5-二羥基苯乙酮2',5'-二羥基苯乙酮
2,5-二羥基乙酰苯
2,5-二羥苯乙酮
2-乙醯氫醌
2',5'-二羥基苯乙酮, 98+%
英文別名
1-(2,5-DIHYDROXYPHENYL)ETHAN-1-ONE1-(2,5-DIHYDROXYPHENYL)ETHANONE
2',5'-DIHYDROXYACETOPHENONE
2,5-DIHYDROXYACETOPHENONE
2,5-DIHYDROXYPHENYL METHYL KETONE
2-ACETYL-1,4-DIHYDROXYBENZENE
2-ACETYLHYDROQUINONE
ACETYLQUINOL
QUINACETOPHENONE
1-(2,5-dihydroxyphenyl)-ethanon
1-Acetyl-2,5-dihydroxybenzene
2,5-Dihydroxy-1-acetylbenzene
2’,5’-dihydroxy-acetophenon
Acetophenone, 2',5'-dihydroxy-
Acetylhydroquinone
2',5'-Dihydroxyacetophenone 2-Acetylhydroquinone
2,5-Dihydroxyacetophenone, 98+%
2-Acethylhydroquinone
Ethanone, 1-(2,5-dihydroxyphenyl)-
2,5-DIHYDROXYACETOPHENONE extrapure
所屬類別
化學(xué)試劑：芳香酮物理化學(xué)性質(zhì)
外觀性狀淡黃綠色針狀結(jié)晶。熔點(diǎn)202-203℃。溶于醇，難溶于醚和苯，幾乎不溶于冷水。在堿溶液中呈黃色，遇三氧化鐵呈藍(lán)色。能升華。
熔點(diǎn)204-206 °C(lit.)
沸點(diǎn)234.6°C (rough estimate)
密度1.2143 (rough estimate)
折射率1.4447 (estimate)
儲(chǔ)存條件Store below +30°C.
溶解度dioxane: 50 mg/mL, clear
酸度系數(shù)(pKa)9.86±0.18(Predicted)
形態(tài)晶體或結(jié)晶粉末
顏色黃色至黃綠色
水溶解性insoluble
BRN637903
InChIKeyWLDWSGZHNBANIO-UHFFFAOYSA-N
LogP1.274 (est)
CAS 數(shù)據(jù)庫(kù)490-78-8(CAS DataBase Reference)
NIST化學(xué)物質(zhì)信息Ethanone, 1-(2,5-dihydroxyphenyl)-(490-78-8)
EPA化學(xué)物質(zhì)信息Ethanone, 1-(2,5-dihydroxyphenyl)- (490-78-8)
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H315-H319-H335
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼R36/37/38
安全說(shuō)明S26-S36
WGK Germany3
RTECS號(hào)AM7700000
Hazard NoteIrritant
TSCAYes
海關(guān)編碼29145000
2,5-二羥基苯乙酮價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | A12185 | 2',5'-二羥基苯乙酮, 98+% 2',5'-Dihydroxyacetophenone, 98+% | 490-78-8 | 5g | 312元 |
| 2024/11/08 | A12185 | 2',5'-二羥基苯乙酮, 98+% 2',5'-Dihydroxyacetophenone, 98+% | 490-78-8 | 25g | 1073元 |
| 2024/11/08 | A12185 | 2',5'-二羥基苯乙酮, 98+% 2',5'-Dihydroxyacetophenone, 98+% | 490-78-8 | 100g | 4356元 |
常見(jiàn)問(wèn)題列表
生物活性
2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) 是二羥基苯乙酮異構(gòu)體的混合物，用于食品調(diào)味。2',5'-Dihydroxyacetophenone 通過(guò)抑制 iNOS 的表達(dá)來(lái)顯著抑制 NO 的產(chǎn)生。2',5'-Dihydroxyacetophenone 可通過(guò)阻斷 ERK1/2 和 NF-κB 信號(hào)通路來(lái)顯著地降低促炎細(xì)胞因子 TNF-α 和 IL-6 的表達(dá)水平。靶點(diǎn)
| Target | Value |
|
iNOS
() | |
|
ERK1/2
() | |
|
NF-κB
() | |
|
TNF-α
() | |
|
IL-6
() |
體外研究
2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells.