479347-86-9
中文名稱(chēng)
6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮
英文名稱(chēng)
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt
CAS
479347-86-9
分子式
C24H14N8Na2O12S2
分子量
716.524
MOL 文件
479347-86-9.mol
更新日期
2024/11/03 13:10:38
479347-86-9 結(jié)構(gòu)式
基本信息
英文別名
3-dione . 2NaNBQX (sodium salt)
FG 9202 disodium salt
6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2
6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2
3-DIONE . 2NA
FG 9202 DISODIUM SALT
Benzo[f]quinoxaline-7-sulfonamide,1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-,sodium salt(1:2)
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C冷凍
溶解度Soluble in H2O
形態(tài)結(jié)晶固體
顏色橙色
水溶解性溶于水至100mM
穩(wěn)定性儲(chǔ)存在-20°C的冰箱中
常見(jiàn)問(wèn)題列表
生物活性
NBQX disodium (FG9202 disodium) 是高度選擇性，競(jìng)爭(zhēng)型的 AMPA 受體拮抗劑。NBQX disodium 具有神經(jīng)保護(hù)和抗驚厥活性。靶點(diǎn)
AMPA receptor
體外研究
NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex.
體內(nèi)研究
NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ.
NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion.
| Animal Model: | Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ) |
| Dosage: | 20 mg/kg |
| Administration: | IP; for 3 days |
| Result: | Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats. |