| Identification | Back Directory | [Name]
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt | [CAS]
479347-86-9 | [Synonyms]
3-dione . 2Na
NBQX (sodium salt)
FG 9202 disodium salt
6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2
6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2;3-DIONE . 2NA;FG 9202 DISODIUM SALT
Benzo[f]quinoxaline-7-sulfonamide,1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-,sodium salt(1:2) | [Molecular Formula]
C24H14N8Na2O12S2 | [MOL File]
479347-86-9.mol | [Molecular Weight]
716.524 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C Freezer | [solubility ]
Soluble in H2O | [form ]
crystalline solid | [color ]
Orange | [Water Solubility ]
Soluble to 100 mM in water | [Stability:]
Store in Freezer at -20°C |
| Hazard Information | Back Directory | [Chemical Properties]
Deep Red-Brown Solid | [Uses]
A potent and discriminating antagonist for AMPA binding sites. | [Biological Activity]
nbqx disodium salt is a potent, highly selective and competitive antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (ampa) receptors (ampars). the ampar is one type of ionotropic glutamate receptors, well known to be involved in various neurological disorders such as alzheimer disease, schizophrenia, and epilepsy, by mediating long-term potentiation, excitotoxicity, or both. inhibition of ampars with nbqx shows neuroprotective and anticonvulsant activity.1. fukushima k, tabata y, imaizumi y, et al. characterization of human hippocampal neural stem/progenitor cells and their application to physiologically relevant assays for multiple ionotropic glutamate receptors. journal of biomolecular screening, 2014, 19(8): 1174-1184.2. chen w, li ys, gao j, et al. ampa receptor antagonist nbqx decreased seizures by normalization of perineuronal nets. plos one, 2016, 11(11): e0166672. | [storage]
-20°C |
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