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4261-42-1

中文名稱 異葒草素
英文名稱 HOMOORIENTIN
CAS 4261-42-1
分子式 C21H20O11
分子量 448.38
MOL 文件 4261-42-1.mol
更新日期 2024/12/23 09:58:20
4261-42-1 結(jié)構(gòu)式 4261-42-1 結(jié)構(gòu)式

基本信息

中文別名
異葒草苷
異紅草素
異葒草素
異葒草苷、異葒草素
異葒草素,異葒草苷
異葒草苷(標(biāo)準(zhǔn)品)
異葒草素, 來源于葒草
木犀草素-6-C-葡萄糖苷
異葒草素,異葒草苷 ,異葒草素
異葒草苷(異葒草素,異葒草苷 ,異葒草素)
英文別名
ISOORIENTIN
HOMOORIENTIN
IsoorientinI
lespecapittoside
HOMOORIENTIN hplc
HOMOORIENTIN WITH HPLC
LUTEOLIN-6-C-GLUCOSIDE
Isoorientin/HoMoorientin
Luteolin 6-C-β-D-glucoside
HoMoorientin, froM PolygonuM orientale
所屬類別
生物化工:提取物

物理化學(xué)性質(zhì)

外觀性狀黃色粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來源于竹葉,夏枯草,石竹。
熔點(diǎn)245-246°C
沸點(diǎn)856.7±65.0 °C(Predicted)
密度1.759±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度可溶于甲醇:5mg/mL,澄清,無色至黃色
酸度系數(shù)(pKa)5.90±0.40(Predicted)
形態(tài)粉末
顏色黃色
穩(wěn)定性吸濕性
InChIKeyODBRNZZJSYPIDI-VJXVFPJBSA-N
LogP1.580 (est)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
安全說明24/25
WGK Germany3
海關(guān)編碼29389090

應(yīng)用領(lǐng)域

用途1
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。
藥理藥效:保肝作用,抗病毒活性,抗過氧化作用,解焦慮作用。
用途2
異葒草素具有抗心肌缺血的作用。
異葒草素價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-N0767異葒草素
Isoorientin
4261-42-11mg400元
2024/11/08HY-N0767異葒草素
Isoorientin
4261-42-15mg800元
2024/11/08HY-N0767異葒草素
Isoorientin
4261-42-110mM * 1mLin DMSO880元

常見問題列表

生物活性
Isoorientin是一種有效的 COX-2 抑制劑,IC50 值為 39 μM。
靶點(diǎn)

COX-2

39 μM (IC 50 )

體外研究

Isoorientin is a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa. PANC-1 and PATU-8988 cells are grown for 24 hours in the presence of Isoorientin (0, 20, 40, 80, and 160 μM), and a CCK8 solution is added. The cell viability decreases significantly at the concentrations of 20, 40, 80, and 160 μM. After the cells are cultured with Isoorientin (0, 20, 40, 80, and 160 μM for PANC-1; 0, 20, 40, 80, 160, and 320 μM for PATU-8988) for 24 hours, the expression of p-AMPK and AMPK is assessed by Western blotting. After the Isoorientin treatment, the p-AMPK expression is increased. Then, in the shRNA group, the concentration of 80 μM is used to detect the effects of Isoorientin. The expression levels of AMPK and p-AMPK are much lower in the shRNA group than in the wild-type PC cells (WT) and the group that is transfected with a negative control lentivirus (NC).

體內(nèi)研究

Animals treated with Isoorientin at 10?mg/kg and 20?mg/kg body weight have a statistically significant reduction in paw edema, with a mean peak thickness of 1.19±0.05?mm and 1.08±0.04?mm, respectively. This indicated that Isoorientin significantly attenuates paw edema compared with the control group.

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