37000-20-7
中文名稱
凈特羅
英文名稱
N-(2-HYDROXY-5-(1-HYDROXY-2-(2-METHYL-1-PHENYLPROPAN-2-YLAMINO)ETHYL)PHENYL)METHANE
CAS
37000-20-7
分子式
C19H26N2O4S
分子量
378.49
MOL 文件
37000-20-7.mol
37000-20-7 結(jié)構(gòu)式
基本信息
中文別名
凈特羅 英文別名
MJ 9184Zinterol
N-{5-[2-(1,1-DiMethyl-2-phenyl-ethylaMino)-1-hydroxy-ethyl]-2-hydroxy-phenyl}-MethaesulfonaMide
Methanesulfonamide, N-[5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]-
N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamidehydrochloride
物理化學(xué)性質(zhì)
沸點(diǎn)574.3±60.0 °C(Predicted)
密度1.282±0.06 g/cm3(Predicted)
儲(chǔ)存條件Store at +4°C
溶解度Soluble to 5 mM in water and to 100 mM in DMSO
酸度系數(shù)(pKa)8.57±0.50(Predicted)
形態(tài)Powder
顏色White to off-white
凈特羅價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2023/03/20 | HY-14304 | 凈特羅 Zinterol | 37000-20-7 | 1mg | 1550元 |
| 2023/03/20 | HY-14304 | 凈特羅 Zinterol | 37000-20-7 | 10mM * 1mLin DMSO | 3872元 |
| 2023/03/20 | HY-14304 | 凈特羅 Zinterol | 37000-20-7 | 5mg | 4650元 |
常見問題列表
生物活性
Zinterol (MJ 9184) 是一種有效的選擇性 β2-腎上腺素受體 (β2-adrenoceptor) 激動(dòng)劑。Zinterol 增強(qiáng) ICa，EC50 為 2.2 nM。靶點(diǎn)
β2-adrenoceptor
體內(nèi)研究
Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits.
| Animal Model: | In New Zealand White HF rabbits of either sex |
| Dosage: | 1.0 or 2.5 μg/kg |
| Administration: | Intravenous bolus administration; over 5 seconds |
| Result: |
2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits. |