36341-25-0
中文名稱(chēng)
4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚
英文名稱(chēng)
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
CAS
36341-25-0
分子式
C14H11NO2S
分子量
257.31
MOL 文件
36341-25-0.mol
更新日期
2023/03/20 15:41:25
36341-25-0 結(jié)構(gòu)式
基本信息
中文別名
MCF-7細(xì)胞株抑制劑(YL-109)2-(4-羥基-3-甲氧基苯基)苯并噻唑
4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚
英文別名
Y109Y-109
YL-109
Y-109
Y109
Phenol, 4-(2-benzothiazolyl)-2-methoxy-
4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol
4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one
所屬類(lèi)別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml; Ethanol: 1 mg/ml
形態(tài)結(jié)晶固體
顏色Light yellow to yellow
4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-18619 | 4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚 YL-109 | 36341-25-0 | 5mg | 550元 |
| 2024/08/19 | HY-18619 | 4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚 YL-109 | 36341-25-0 | 10mM * 1mLin DMSO | 600元 |
| 2024/08/19 | HY-18619 | 4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚 YL-109 | 36341-25-0 | 10mg | 900元 |
常見(jiàn)問(wèn)題列表
生物活性
YL-109是新型的抗腫瘤試劑，在體內(nèi)外可抑制乳腺癌細(xì)胞的生長(zhǎng)和侵襲。體外研究
YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells.
Cell Proliferation Assay
| Cell Line: | MCF-7 and MDA-MB-231 cells |
| Concentration: | 0.001, 0.01, 0.1, 1, 10 μM |
| Incubation Time: | 96 hours |
| Result: | Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively). |
體內(nèi)研究
YL-109 (15 mg/kg; s.c. for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo.
| Animal Model: | BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells |
| Dosage: | 15 mg/kg |
| Administration: | S.c. every 2 days for 63 days |
| Result: | Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells. |