339163-65-4
339163-65-4 結(jié)構(gòu)式
基本信息
人直腸腺癌腺癌細(xì)胞
RCM-1人胰腺癌細(xì)胞
RCM-1人直腸腺癌腺癌細(xì)胞
2-((2-氧代-2-(噻吩-2-基)乙基)硫基)-4,6-二(噻吩-2-基)吡啶-3-腈
RCM1
CMH7
CMD2A
CMD1FF
RCM 1 NEW
Troponin I ELISA Kit
troponin I type 3 (cardiac)
Inhibitor,RCM 1,inhibit,RCM1,RCM-1
Anti-TNNI3 antibody produced in goat
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-19979 | 2-((2-氧代-2-(噻吩-2-基)乙基)硫基)-4,6-二(噻吩-2-基)吡啶-3-腈 RCM-1 | 339163-65-4 | 5mg | 1500元 |
| 2024/11/08 | HY-19979 | 2-((2-氧代-2-(噻吩-2-基)乙基)硫基)-4,6-二(噻吩-2-基)吡啶-3-腈 RCM-1 | 339163-65-4 | 10mM * 1mLin DMSO | 1650元 |
| 2024/11/08 | S6898 | 2-((2-氧代-2-(噻吩-2-基)乙基)硫基)-4,6-二(噻吩-2-基)吡啶-3-腈 RCM-1 | 339163-65-4 | 5mg | 1870元 |
常見(jiàn)問(wèn)題列表
| Target | Value |
|
FOXM1
() | |
|
IL-13
() | |
|
STAT6
() | |
|
β-catenin
() |
RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1, a transcription factor critical for the differentiation of goblet cells from airway progenitor cells. In cultured airway epithelial cells, RCM-1 reduces IL-13 and STAT6 signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3, which are key transcriptional regulators of goblet cell differentiation.
RCM-1 reduces airway resistance, increased lung compliance, and decreased proinflammatory cytokine production in mice exposed to the house dust mite and interleukin-13 (IL-13), which triggers goblet cell metaplasia. In mice, RCM-1 reduces IL-13 and STAT6 signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3.