31059-54-8
中文名稱
2-(BETA-萘甲?；?乙基三甲基碘化銨
英文名稱
2-naphthoylethyltrimethylammonium
CAS
31059-54-8
分子式
C16H20NO.I
MOL 文件
31059-54-8.mol
更新日期
2023/03/20 15:41:29
31059-54-8 結(jié)構(gòu)式
基本信息
中文別名
2-(BETA-萘甲?；?乙基三甲基碘化銨 英文別名
β-NETAΑ-NETA
2-naphthoylethyltrimethylammonium
2-(beta-Naphthoyl)ethyltrimethylammonium iodide
2-Dimethylaminoethyl 2-naphthyl ketone methiodide
trimethyl-(3-naphthalen-2-yl-3-oxopropyl)azanium:iodide
物理化學(xué)性質(zhì)
儲(chǔ)存條件Store at -20°C, protect from light, stored under nitrogen
溶解度DMSO: 3mg/ml; Methanol: Soluble
形態(tài)固體
顏色White to off-white
常見問題列表
生物活性
β-NETA 是一種有效的，非競爭性的膽堿乙酰轉(zhuǎn)移酶 (ChA；IC50=76 μM) 和膽堿酯酶 (ChE; IC50=40 μM) 抑制劑。β-NETA 微弱的抑制乙酰膽堿酯 (AChE; IC50=1 mM)。靶點(diǎn)
IC50: 76 μM (ChA); 40 μM (ChE); 1 mM (AChE)
體外研究
β-NETA exhibits no effects at muscarinic receptors, ganglionic nicotinic receptors, skeletal muscular nicotinic receptors, cholinesterases or carnitine acetyltransferase at concentrations which inhibits ChA. At concentrations higher than the IC50 value to inhibit ChA, β-NETA antagonizes the effect of acetylcholine (ED50=100 μM), histamine and KCl-induced contractions in the guinea pig longitudinal ileal muscle.