成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁(yè)>CAS數(shù)據(jù)庫(kù)列表>3105-97-3

3105-97-3

中文名稱(chēng) 海恩酮
英文名稱(chēng) Hycanthone
CAS 3105-97-3
分子式 C20H24N2O2S
分子量 356.48
MOL 文件 3105-97-3.mol
更新日期 2023/03/20 15:41:19
3105-97-3 結(jié)構(gòu)式 3105-97-3 結(jié)構(gòu)式

基本信息

中文別名
海恩酮
羥甲硫蒽酮
1-((2-(二乙基氨基)乙基)氨基)-4-(羥甲基)-9H-噻噸-9-酮
英文別名
ETRENOL
hycanthon
nsc-134434
Win 249-33
HYCANTHONE
Etrenol(mesylate)
lucanthonemetabolite
1-(2-diethylaminoethylamino)-4-methylol-thioxanthen-9-one
1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one
1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-9h-thioxanthen-9-on

物理化學(xué)性質(zhì)

外觀(guān)性狀淡黃色至黃橙色結(jié)晶粉末。
熔點(diǎn)100.6-102.8°
沸點(diǎn)570.5±50.0 °C(Predicted)
密度1.1269 (rough estimate)
折射率1.6000 (estimate)
儲(chǔ)存條件−20°C
溶解度DMSO : 30 mg/mL (84.16 mM)
酸度系數(shù)(pKa)pKa 3.40 (Uncertain)
形態(tài)Solid
顏色Yellow to orange
EPA化學(xué)物質(zhì)信息Hycanthone (3105-97-3)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
警示詞危險(xiǎn)
危險(xiǎn)性描述H302-H332-H350-H312
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類(lèi)別碼45-46-20/21/22
安全說(shuō)明53-36/37/39-45
WGK Germany3
RTECS號(hào)XO1590000

應(yīng)用領(lǐng)域

用途1
海恩酮(Hycanthone)是一種具有抗血吸蟲(chóng)活性和潛在抗腫瘤活性的Lucanthorne的硫雜噸衍生物。海恩酮干擾寄生蟲(chóng)的神經(jīng)功能,導(dǎo)致寄生蟲(chóng)癱瘓和死亡。它也能插入DNA并在體外抑制RNA的合成。

圖譜信息

海恩酮價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2025/02/08HY-B1099海恩酮
Hycanthone
3105-97-35 mg312元
2025/02/08HY-B1099海恩酮
Hycanthone
3105-97-310mg500元
2025/02/08HY-B1099海恩酮
Hycanthone
3105-97-310mM * 1mLin DMSO550元

常見(jiàn)問(wèn)題列表

生物活性
Hycanthone 是噻噸酮類(lèi)的 DNA 嵌入劑 (DNA intercalator),可抑制 RNA 合成以及 DNA 拓?fù)洚悩?gòu)酶 I 和 II。Hycanthone 通過(guò)直接蛋白質(zhì)結(jié)合來(lái)抑制核酸生物合成并抑制嘌呤內(nèi)切核酸酶1 (APE1),KD 為 10 nM。Hycanthone 是 Lucanthone (HY-B2098) 的生物活性代謝產(chǎn)物,具有抗血吸蟲(chóng)病藥物。
靶點(diǎn)

Topoisomerase I

Topoisomerase II

體外研究

Hycanthone has an IC 50 of 80 nM for inhibition of APE1 incision of depurinated plasmid DNA.
Hycanthone (0.05-100 μM; for 2 h) promotes APE1 cleavage in presence of Cycloheximide (CHX) and this cleavage is inhibited by 1% DMSO.
Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Results reveal that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively reduces viral interferon yields as much as 73% compare to that of controls.

體內(nèi)研究

Results show that the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease after treatment with Hycanthone. Immature worms are totally unaffected by Hycanthone at all times tested. Male worms treated with Hycanthone show signs of a possible partial recovery from the initial low levels of incorporation. The incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50% in the first four days after treatment. Results show that, 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules.

"3105-97-3" 相關(guān)產(chǎn)品信息
64506-49-6 26973-24-0 78-40-0 492-22-8