29734-68-7
中文名稱
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
英文名稱
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
CAS
29734-68-7
分子式
C16H21NO3.BrH
分子量
356.25
MOL 文件
29734-68-7.mol
29734-68-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T11041(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
英文別名
DHβE hydrobromide-erythroidineHydrobromide
-erythroidine hydrobromide
Dihydro-2-erythroidine Hydrobromide
DIHYDRO-B-ERYTHROIDINE HYDROBROMIDE
Dihydro-β-erythroidine hydrobromide
Dihydro-β-erythroidine hydrobromide
DIHYDRO-BETA-ERYTHROIDINE HYDROBROMIDE
DIHYDRO-B-ERYTHROIDINE HYDROBROMIDE COMP ETITIVE NICOTINIC
3β-1,6-Didehydro-14,17-dihydro-3-methoxy-16(15H)-oxaerythrinan-15-one hydrobromide
物理化學(xué)性質(zhì)
儲(chǔ)存條件Desiccate at RT
溶解度ethanol: 5mg/mL
溶解度乙醇：5mg/mL
熔點(diǎn)219-229 °C (decomp)
形態(tài)solid
顏色white
常見問題列表
生物活性
Dihydro-β-erythroidine (DHβE) hydrobromide 是一種有效競爭性的，具有口服活性的神經(jīng) nAChRs 拮抗劑。Dihydro-β-erythroidine hydrobromide 對(duì) α4β4 和 α4β2 有選擇性，IC50 分別為 0.19 和 0.37 μM。具有抗抑郁類活性。體內(nèi)研究
Dihydro-Beta-Erythroidine hydrobromide (DHβE hydrobromide; 10 nmol/0.5?μL) is infused into the respective areas prior to a systemic nicotine injection (0.2?mg/kg; SC). DHβE infused into the ventral tegmental area (VTA), nucleus accumbens (NAcc), or infralimbic (IL) cortex, but not prelimbic (PrL) cortex, attenuated nicotine-enhanced responding for a conditioned reinforcer (CRf).
The co-administration of Dihydro-Beta-Erythroidine hydrobromide (5.0 mg/kg; s.c) with nicotine (0.2 and 0.4 mg/kg; s.c.) prevents the development of conditioned taste aversions (CTAs).
| Animal Model: | Male hooded Lister rats |
| Dosage: | 0.5, 1.6 and 5.0 mg/kg |
| Administration: | S.c. |
| Result: | A complete blockade of the nicotine effect produced by the training dose of nicotine (0.2 mg/kg). |