成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>28822-58-4

28822-58-4

中文名稱 IBMX, 3-異丁基-1-甲基黃嘌呤
英文名稱 3-ISOBUTYL-1-METHYLXANTHINE
CAS 28822-58-4
EINECS 編號 249-259-3
分子式 C10H14N4O2
MDL 編號 MFCD00005584
分子量 222.24
MOL 文件 28822-58-4.mol
更新日期 2025/02/21 10:08:15
28822-58-4 結(jié)構(gòu)式 28822-58-4 結(jié)構(gòu)式

基本信息

中文別名
IBMX, 3-異丁基-1-甲基黃嘌呤
3-異丁基-1-甲基黃嘌呤
1-甲基-3-異丁基黃嘌呤
英文別名
1-METHYL-3-ISOBUTYL XANTHINE
3-ISOBUTYL-1-METHYL-2,6(1H,3H)-PURINEDIONE
3-ISOBUTYL-1-METHYLXANTHINE
3-ISOBUTYL-I-METHYLXANTHINE
IBMX
MIX
1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-
3,7-dihydro-1-methyl-3-(2-methylpropyl)-1h-purine-6-dione
3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione
3-Isobutyl-1-methylanxthine
3-isobutyl-1-methyl-xanthin
IMX
Isobutylmethylxanthine
Methylisobutylxanthine
SC 2964
Xanthine, 3-Isobutyl-1-methyl-
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
3,7-dihydro-3-isobutyl-1-methyl-1H-purine-2,6-dione
3-ISOBUTYL-1-METHYLXANTHINE SIGMAULTRA
Isobutyl-1-methylxanthine
所屬類別
生物化工:核苷酸及其類似物

物理化學(xué)性質(zhì)

熔點(diǎn)200-201 °C(lit.)
熔點(diǎn)200-201 °C(lit.)
沸點(diǎn)363.42°C (rough estimate)
密度1.2042 (rough estimate)
折射率1.6500 (estimate)
儲存條件−20°C
儲存條件-20°C
溶解度DMSO: 1 M with gentle warming
溶解度DMSO:1 M,慢慢升溫
酸度系數(shù)(pKa)8.61±0.70(Predicted)
形態(tài)powder
顏色off-white
BRN247859
穩(wěn)定性可在-20°C下的DMSO或乙醇溶液保存長達(dá)3個(gè)月。
InChIKeyAPIXJSLKIYYUKG-UHFFFAOYSA-N
CAS 數(shù)據(jù)庫28822-58-4(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼22
危險(xiǎn)類別碼R22
安全說明24/25
安全說明S24/25
WGK Germany3
WGK Germany3
RTECS號ZD8500000
海關(guān)編碼29335990

應(yīng)用領(lǐng)域

用途一
cAMP 和 cGMP 磷酸二脂酶的非專一性抑制劑。IBMX抑制了磷酸二脂酶,cAMP的增加激活了PKA ,其結(jié)果是減少增殖,增加分化和誘發(fā)凋亡. IBMX抑制由苯腎上腺素誘導(dǎo)的色胺(來自于神經(jīng)內(nèi)分泌上皮細(xì)胞的減少粘液IC50: 1.3 μM)的減少 。也作為腺苷受體拮抗劑。

知名試劑公司產(chǎn)品信息

3-異丁基-1-甲基黃嘌呤價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2025/02/08HY-123183-異丁基-1-甲基黃嘌呤
IBMX
28822-58-45 mg181元
2025/02/08HY-123183-異丁基-1-甲基黃嘌呤
IBMX
28822-58-410mM * 1mLin DMSO199元
2025/02/08HY-123183-異丁基-1-甲基黃嘌呤
IBMX
28822-58-410 mg240元

常見問題列表

生物活性
IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine)是一種非特異性phosphodiesterase (PDE)抑制劑,對PDE3、PDE4、PDE5的IC50值分別為6.5±1.2, 26.3±3.9 和 31.7±5.3 μM。它能增強(qiáng)細(xì)胞內(nèi)cAMP水平,是adenosine (A1) receptor拮抗劑。
靶點(diǎn)
TargetValue
PDE3
()
6.5 μM
PDE4
()
26.3 μM
PDE5
()
31.7 μM
體外研究

At 100 μM, KMUP-1 (a xanthine derivative) and IBMX are the most effective at inducing tracheal relaxation; the magnitude of the relaxation responses induced by KMUP-1 and IBMX are not significantly different. IBMX (100 μM) activates renal outer medullary K + (ROMK) channels (n=6, P<0.05) and prevents further channel activation by ANG II (n=6, P=NS) or cGMP. Of note is that pretreatment of cortical collecting duct (CCDs) isolated from high-K + (HK)-fed rats with IBMX (100 μM) for 20 min leads to a significant increase in tubular cAMP content to 1.43±0.35 pg/mm tubule length (n=14) compare with that measured in vehicle-treated controls (0.61±0.13 pg/mm tubule length, n=12, P<0.05).

體內(nèi)研究

IBMX, a non-selective PDE inhibitor significantly decreases the liver glycogen storage (mg/g, IBMX 22±1.5 P<0.001). In comparison with the control group, IBMX and mc5 significantly increase plasma glucose (blood glucose, mg/dl, control=141±3, IBMX=210±17 P<0.001 and mc5=191±13 P<0.01) while other test compounds (mc1, mc6, MCPIP and Win 47203) do not produce significant effect (control=141±3, mc1 160±7, mc6 175±9, MCPIP 179±8 and Win 47203 116±2 P>0.05) also mc2 does not change plasma glucose (control=141±3 and mc2=145±5). IBMX has the highest efficacy on increasing plasma glucose. Treatments with IBMX and Apocynin significantly decrease cold-induced elevation of right ventricular (RV) systolic pressure (23.5±1.8 and 24.2±0.6 mmHg, respectively) although they do not decrease RV pressure to the warm control levels. IBMX or Apocynin significantly reduces medial layer thickness (19.0±0.9, and 16.9±0.8 μm, respectively) and increases lumen diameter (62.7±4.2, and 59.5±4.3 μm, respectively) of small PAs in cold-exposed rats.

"28822-58-4" 相關(guān)產(chǎn)品信息
28822-58-4 6136-37-4