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25913-34-2

中文名稱 鹽酸替諾立定
英文名稱 ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate monohydrochloride
CAS 25913-34-2
分子式 C17H21ClN2O2S
分子量 352.879
MOL 文件 25913-34-2.mol
更新日期 2024/11/05 13:11:13
25913-34-2 結(jié)構(gòu)式 25913-34-2 結(jié)構(gòu)式

基本信息

中文別名
鹽酸替諾立定
鹽酸替諾立定雜質(zhì)
2-氨基-6-芐基-4,5,6,7-四氫噻吩并[2,3-C]吡啶-3-甲酸乙酯鹽酸鹽
英文別名
Dimaten
Nonflamin
Tinoridine HCl
Einecs 247-342-9
Y-3642 hydrochloride
Tinoridine Hydrochloride
Tenolinidine hydrochloride
Tenocyclidine hydrochloride
Tinoridine Hydrochloride USP/EP/BP
Tenoridine Hydrochloride Impurities
所屬類別
原料藥:非甾抗炎藥

物理化學(xué)性質(zhì)

熔點234-235° (dec)
儲存條件Keep in dark place,Inert atmosphere,Room temperature
溶解度DMSO : ≥ 31 mg/mL (87.85 mM)
形態(tài)Solid
顏色White to yellow

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302
毒性LD50 orally in mice: 1601 mg/kg (Nakanishi, 1974)
鹽酸替諾立定價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-111354鹽酸替諾立定
Tinoridine hydrochloride
25913-34-25mg750元
2024/11/08HY-111354鹽酸替諾立定
Tinoridine hydrochloride
25913-34-210mM * 1mLin DMSO825元
2024/11/08HY-111354鹽酸替諾立定
Tinoridine hydrochloride
25913-34-210mg1120元

常見問題列表

生物活性
Tinoridine hydrochloride (Y-3642)是一種非類固醇的消炎藥物,具有有效的抗氧化活性。
體外研究

Tinoridine reduces a stable free radical, diphenyl-p-picrylhydrazyl, in the molar ratio of about 1:2, indicating its free radical scavenging ability. Tinoridine inhibits the lipid peroxidation in rat liver microsomes induced by xanthine-xanthine oxidase system in the presence of ADP and Fe 2+ , in which hydroxyl radical is formed. Tinoridine is demonstrated to be oxidized in the course of the lipid peroxidation by following the fluorescence derived from the oxidation product of tinoridine. It is also oxidized by the xanthine-xanthine oxidase system in the presence of Fe 2+ , but its oxidation is slow in the absence of Fe 2+ and almost completely inhibited by catalase. Tinoridine is also oxidized by H 2 O 2 -Fe 2+ system producing OH (Fenton reaction), but it does not affect the reduction of cytochrome c caused by superoxide radical.

體內(nèi)研究

CCl 4 aministration produces a marked decrease in the concentrations of liver microsomal cytochrome P-450 and G6Pase, indicating that hepatic endoplasmic reticulum function is disrupted. Prior treatment of the animals with tinoridine (100 mg/kg) significantly reduces the CCl 4 -induced alterations in the enzyme activities, and a rapid recovery toward the normal values is observed.

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