256477-09-5
中文名稱
NULL
英文名稱
UK-371804
CAS
256477-09-5
更新日期
2024/12/15 19:35:15
分子式
C14H16ClN5O4S
分子量
385.83
MOL 文件
256477-09-5.mol
256477-09-5 結(jié)構(gòu)式
基本信息
中文別名
化合物UK371804 英文別名
UK-371804Urokinase inhitibor 1
Urokinase inhibitor 1
UK-371804 (Urokinase inhitibor 1)
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度DMSO:5.0(Max Conc. mg/mL);2.59(Max Conc. mM)
形態(tài)結(jié)晶固體
顏色White to off-white
CAS 數(shù)據(jù)庫256477-09-5
常見問題列表
生物活性
UK-371804是尿嘧啶型纖溶酶原激活物 (uPA) 的抑制劑，Ki值為10 nM。靶點
Ki: 10 nM (uPA)
體外研究
UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC 50 =0.89 μM). UK-371804 has its excellent enzyme potency (K i =10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
體內(nèi)研究
In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM.