2244161-71-3
中文名稱
Dolutegravir Impurity 7
英文名稱
Dolutegravir Impurity 7
CAS
2244161-71-3
分子式
C20H21N3O5
分子量
383.4
MOL 文件
2244161-71-3.mol
2244161-71-3 結(jié)構(gòu)式
基本信息
中文別名
杜魯特韋雜質(zhì)4度魯特韋雜質(zhì)7
度魯特韋 雜質(zhì)11
英文別名
Dolutegravir Impurity 72,4-Di-Desfluoro Dolutegravir Sodium salt
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品應(yīng)用領(lǐng)域
用途一
Desdifluoro Dolutegravir is impurity B of Dolutegravir(D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.