1357289-29-2
中文名稱
度魯特韋雜質(zhì)6
英文名稱
Dolutegravir Impurity 6
CAS
1357289-29-2
分子式
C20H19F2N3O5
分子量
419.38
MOL 文件
1357289-29-2.mol
更新日期
2024/12/18 16:46:15
1357289-29-2 結(jié)構(gòu)式
基本信息
中文別名
度魯特韋雜質(zhì)6度魯特韋雜質(zhì)B
杜魯特韋雜質(zhì)3
多替拉韋雜質(zhì)12
度魯特韋雜質(zhì)42
多替拉韋RR異構(gòu)體
度魯特韋非對映異構(gòu)體1
DOLUTEGRAVIR雜質(zhì)B
英文別名
Dolutegravir RR IsomerDolutegravir Impurity 6
Doultegravirr RR Isomer
Dolutegravir Impurity 42
(4R,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aR)-
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品應(yīng)用領(lǐng)域
用途一
Dolutegravir RR Isomer is an isomer of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.