22338-71-2
中文名稱
遠(yuǎn)志酸
英文名稱
Polygalacic acid
CAS
22338-71-2
分子式
C30H48O6
分子量
504.7
MOL 文件
22338-71-2.mol
更新日期
2024/10/20 10:22:53
22338-71-2 結(jié)構(gòu)式
基本信息
中文別名
遠(yuǎn)志酸遠(yuǎn)志酸(標(biāo)準(zhǔn)品)
遠(yuǎn)志酸, 來(lái)源于遠(yuǎn)志
毛果一枝黃花皂苷元G
遠(yuǎn)志酸,毛果一枝黃花皂苷元G
英文別名
PolygalacicPolygalacic acid
Virgaureagenin G
Polygalacic acid, >=98%
(4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid
Polygalacic acid, 98%, from Polygala tenuifolia Willd.
(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-
Polygalacic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
所屬類別
生物化工：提取物物理化學(xué)性質(zhì)
熔點(diǎn)300-305 °C (sublm)
沸點(diǎn)638.1±55.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
儲(chǔ)存條件4°C, protect from light
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)4.41±0.70(Predicted)
形態(tài)粉末
顏色White to off-white
遠(yuǎn)志酸價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-N0801 | 遠(yuǎn)志酸 Polygalacic acid | 22338-71-2 | 1mg | 1100元 |
| 2024/08/19 | S9386 | 遠(yuǎn)志酸 Polygalacic acid | 22338-71-2 | 1mg | 1204.48元 |
| 2024/08/19 | HY-N0801 | 遠(yuǎn)志酸 Polygalacic acid | 22338-71-2 | 5mg | 3200元 |
常見問(wèn)題列表
生物活性
Polygalacic acid 是從遠(yuǎn)志屬植物（Polygala paenea L.）分離出的三萜類四羥酸。Polygalacic acid (0-100μM; 24h) 可以顯著降低 MMP-3、MMP-9、MMP-13 和 COX-2 的mRNA表達(dá)，這些因子的表達(dá)由IL-1β誘導(dǎo)可顯著增加，并呈現(xiàn)出劑量依賴性。體外研究
Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid.
RT-PCR
| Cell Line: | Chondrocyte cells |
| Concentration: | 50 μM; 100 μM |
| Incubation Time: | 24 hours |
| Result: | Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. |
Western Blot Analysis
| Cell Line: | Chondrocyte cells |
| Concentration: | 50 μM; 100 μM |
| Incubation Time: | 6 hours |
| Result: | Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes. |