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22338-71-2

中文名稱 遠(yuǎn)志酸
英文名稱 Polygalacic acid
CAS 22338-71-2
分子式 C30H48O6
分子量 504.7
MOL 文件 22338-71-2.mol
更新日期 2024/10/20 10:22:53
22338-71-2 結(jié)構(gòu)式 22338-71-2 結(jié)構(gòu)式

基本信息

中文別名
遠(yuǎn)志酸
遠(yuǎn)志酸(標(biāo)準(zhǔn)品)
遠(yuǎn)志酸, 來(lái)源于遠(yuǎn)志
毛果一枝黃花皂苷元G
遠(yuǎn)志酸,毛果一枝黃花皂苷元G
英文別名
Polygalacic
Polygalacic acid
Virgaureagenin G
Polygalacic acid, >=98%
(4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid
Polygalacic acid, 98%, from Polygala tenuifolia Willd.
(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-
Polygalacic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
所屬類別
生物化工:提取物

物理化學(xué)性質(zhì)

熔點(diǎn)300-305 °C (sublm)
沸點(diǎn)638.1±55.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
儲(chǔ)存條件4°C, protect from light
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)4.41±0.70(Predicted)
形態(tài)粉末
顏色White to off-white

應(yīng)用領(lǐng)域

用途1
安神,祛痰,消腫等,臨床多用于治療支氣管炎和引產(chǎn),催產(chǎn)等。

安全數(shù)據(jù)

海關(guān)編碼29163990
遠(yuǎn)志酸價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19HY-N0801遠(yuǎn)志酸
Polygalacic acid
22338-71-21mg1100元
2024/08/19S9386遠(yuǎn)志酸
Polygalacic acid
22338-71-21mg1204.48元
2024/08/19HY-N0801遠(yuǎn)志酸
Polygalacic acid
22338-71-25mg3200元

常見問(wèn)題列表

生物活性
Polygalacic acid 是從遠(yuǎn)志屬植物(Polygala paenea L.)分離出的三萜類四羥酸。Polygalacic acid (0-100μM; 24h) 可以顯著降低 MMP-3、MMP-9、MMP-13 和 COX-2 的mRNA表達(dá),這些因子的表達(dá)由IL-1β誘導(dǎo)可顯著增加,并呈現(xiàn)出劑量依賴性。
體外研究

Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid.

RT-PCR

Cell Line: Chondrocyte cells
Concentration: 50 μM; 100 μM
Incubation Time: 24 hours
Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression.

Western Blot Analysis

Cell Line: Chondrocyte cells
Concentration: 50 μM; 100 μM
Incubation Time: 6 hours
Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.
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