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2188-68-3

中文名稱 鹽酸石蒜堿
英文名稱 Lycorine hydrochloride
CAS 2188-68-3
分子式 C16H17NO4
分子量 287.31
MOL 文件 2188-68-3.mol
更新日期 2024/10/29 14:58:02
2188-68-3 結(jié)構(gòu)式 2188-68-3 結(jié)構(gòu)式

基本信息

中文別名
水仙堿
石蒜堿
石蕊堿
鹽酸石蒜堿
鹽酸石蒜堿(標(biāo)準(zhǔn)品)
石蒜堿鹽酸鹽對照品,
鹽酸石蒜堿(石蒜堿鹽酸鹽
異鼠李素-3-Β-D-蕓香糖甙
鹽酸石蒜堿, 96%(HPLC)
鹽酸石蒜堿(石蒜堿鹽酸鹽,水仙堿)
英文別名
LYCORIN
LYCORINE
(-)-LYCORINE
NARCISSIN(P)
Lycorine chloride
Hydrochloric Lycorine
Licorin hydrochloride
Lycorine hydrochloride
Licorine hydrochloride
Amarylline hydrochloride

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機溶劑,來源于石蒜鱗莖。
熔點206 °C
儲存條件Keep in dark place,Inert atmosphere,2-8°C
溶解度溶于水(15mg/毫升)
形態(tài)粉末
顏色白色至灰白色
穩(wěn)定性在-20°C下的水溶液可保存長達1個月。

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS06
警示詞危險
危險性描述H301
危險品標(biāo)志T
危險類別碼25
安全說明45
危險品運輸編號UN 2811 6.1/PG 3
WGK Germany3

應(yīng)用領(lǐng)域

用途1
一種選擇性的PTC抑制劑。
用途2
肽轉(zhuǎn)移酶中心(peptidyl transferase center ,PTC)的選擇性抑制劑。
鹽酸石蒜堿價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/08/19HY-N0289鹽酸石蒜堿
Lycorine hydrochloride
2188-68-325mg500元
2024/08/19HY-N0289鹽酸石蒜堿
Lycorine hydrochloride
2188-68-310mM * 1mLin DMSO550元
2024/08/19HY-N0289鹽酸石蒜堿
Lycorine hydrochloride
2188-68-350mg800元

常見問題列表

生物活性
Lycorine hydrochloride 是石蒜的主要活性成分,也是黑色素瘤血管生成抑制劑,具有抗腫瘤活性。Lycorine hydrochloride 能有效抑制 Hey1B 細胞的有絲分裂增殖 (IC50 為 1.2 μM)。
靶點

IC50: 1.2 μM (Hey1B cells )

體外研究

Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected.
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.

RT-PCR

Cell Line: C8161 cells
Concentration: 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
Incubation Time: 48 hours
Result: Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells.

Western Blot Analysis

Cell Line: C8161 cells
Concentration: 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
Incubation Time: 48 hours
Result: Markedly reduced VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
體內(nèi)研究

Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.

Animal Model: 6- to 8-week-old BALB/C nude mice
Dosage: 0 μg, 7.5 μg, 15 μg
Administration: Subcutaneous injection; for 14 days
Result: Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
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