21200-24-8
21200-24-8 結(jié)構(gòu)式
基本信息
中文別名
吲哚霉素 英文別名
Pa-155-A(-)-INDOLMYCIN
(S)-5-[(1R)-1-(1H-Indol-3-yl)ethyl]-2-(methylamino)-4(5H)-oxazolone
[5S,(-)]-5-[(R)-1-(1H-Indol-3-yl)ethyl]-2-methylamino-2-oxazolin-4-one
4(5H)-Oxazolone, 5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-, (5S)-
物理化學(xué)性質(zhì)
熔點(diǎn)209-210°
比旋光度D25 -214° (c = 2 in methanol)
沸點(diǎn)420.8±37.0 °C(Predicted)
密度1.36±0.1 g/cm3(Predicted)
儲(chǔ)存條件Store at -20°C, protect from light
溶解度Soluble in ethanol;methanol;DMSO;dimethyl formamide
酸度系數(shù)(pKa)16.65±0.30(Predicted)
形態(tài)粉末
顏色白色
常見(jiàn)問(wèn)題列表
生物活性
Indolmycin (TAK-083) 是一種抗生素，是原核生物色氨酸-tRNA 連接酶 (TrpS) 的競(jìng)爭(zhēng)性抑制劑。Indolmycin (TAK-083) 具有抗菌和抗病毒活性。體外研究
Indolmycin was bacteriostatic and demonstrated good activity against MSSA (methicillinsusceptible Staphylococcus aureus), MRSA (methicillin-resistant S. aureus) and VISA (vancomycinintermediate S. aureus), including strains resistant to mupirocin or fusidic acid. Indolmycin MICs for 20 strains ranged from 8 to 32 mg/L, whereas a single strain exhibited high-level resistance (MIC 128 mg/L).