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210344-98-2

中文名稱 CASPASE-8抑制劑
英文名稱 CASPASE-8 INHIBITOR II
CAS 210344-98-2
分子式 C30H43FN4O11
分子量 654.68
MOL 文件 210344-98-2.mol
更新日期 2024/10/18 19:54:04
210344-98-2 結(jié)構(gòu)式 210344-98-2 結(jié)構(gòu)式

基本信息

中文別名
CASPASE-8抑制劑
(5S,8S,11S,14S)-5-((S)-仲丁基)-14-(2-氟乙?;?-11-((R)-1-羥乙基)-8-(3-甲氧基-3-氧代丙基)-3,6,9,12-四氧代-1-苯基-2-氧雜-4,7,10,13-四氮雜十六烷-16-酸甲酯
英文別名
Z-IETD-FMK
Z-IETD-FMK?, >98%
Z-IE(OME)TD(OME)-FMK
CASPASE-8 INHIBITOR II
GRANZYME B INHIBITOR III
Z-ILE-GLU(OME)-THR-ASP(OME)-FMK
Z-IE(OME)TD(OME)-FLUOROMETHYLKETONE
CASPASE-8 INHIBITOR
Z-IE(OME)TD(OME)-FMK
Z-ILE-GLU(OME)-THR-ASP(OME)-FLUOROMETHYLKETONE
Z-ILE-GLU(OME)-THR-DL-ASP(OME)-FLUOROMETHYLKETONE

物理化學(xué)性質(zhì)

沸點(diǎn)925.7±65.0 °C(Predicted)
密度1.247±0.06 g/cm3(Predicted)
儲(chǔ)存條件Inert atmosphere,2-8°C
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)11.12±0.46(Predicted)
形態(tài)粉末
顏色White to light yellow
CASPASE-8抑制劑價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08S7314CASPASE-8抑制劑
Z-IETD-FMK
210344-98-21mg1624.01元
2024/11/08S7314CASPASE-8抑制劑
Z-IETD-FMK
210344-98-25mg4832.1元
2024/11/08S7314Z-IETD-FMK210344-98-210mM (1mL in DMSO)5561.01元

常見問題列表

生物活性
Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK)是一種特異性Caspase-8抑制劑。
靶點(diǎn)
TargetValue
Caspase-8
體外研究

Z-IETD-FMK causes full inhibition only of the proapoptotic effect of TNFα with an IC 50 of 0.46 μM. Z-IETD-FMK and Z-VAD-FMK at non-toxic doses are found to be immunosuppressive and inhibit human T cell proliferation induced by mitogens and IL-2. They are shown to block NF-κB in activated primary T cells, but have little inhibitory effect on the secretion of IL-2 and IFN-γ during T cell activation. Z-IETD-FMK inhibits the cleavage of caspase-8 and only partially inhibits the cleavage of caspase-3 and PARP. Z-IETD-FMK can prevent the execution of apoptosis in retinal cells exposed to different apoptotic stimuli.

體內(nèi)研究

Pharmacological inhibition of caspase-8 by z-IETD-FMK robustly reduces tumour outgrowth and this is closely associated with a reduction in the release of pro-inflammatory cytokines, IL-6, TNF-α, IL-18, IL-1α, IL-33, but not IL-1β. Furthermore, inhibition of caspase-8 reduces the recruitment of innate suppressive cells, such as myeloid-derived suppressor cells, but not of regulatory T cells to lungs of tumour-bearing mice.

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