2062-78-4
2062-78-4 結構式
基本信息
哌莫奇特
匹莫奇特
匹莫齊特
PIMOZIDE
1-(1-(4,4-bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinon
1-(1-(4,4-bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinone
1-(4,4-bis(p-fluorophenyl)butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine
mcn-jr-6238
orap
3-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidyl)-1H-benzimidazol-2-one
2H-Benzimidazol-2-one, 1-1-4,4-bis(4-fluorophenyl)butyl-4-piperidinyl-1,3-dihydro-
OPIRAN
1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazole-2-one
1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidyl]-1,3-dihydro-2H-benzimidazol-2-one
R 6238
物理化學性質
常見問題列表
分子印跡技術是以待測目標分子為模板分子，將具有結構上互補的功能性單體通過共價或非共價鍵與模板分子結合形成單體模板分子復合物，再加入交聯(lián)劑使之與單體進行聚合反應形成模板分子聚合物，反應完成后通過物理或化學方法去除模板分子，得到分子印跡聚合物，在聚合物中形成與原印跡分子空間結構互補并且具有多重識別位點的空穴
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STAT3
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STAT5
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Dopamine D2 receptor 1.4 nM (Ki) |
Dopamine D3 receptor 2.5 nM (Ki) |
Dopamine D1 receptor 588 nM (Ki) |
α1-adrenoceptor 39 nM (Ki) |
Pimozide is a dopamine receptor antagonist, with K i s of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively; also has affinity at α1-adrenoceptor and 5-HT1A, with K i s of 39 nM and 310 nM, respectively. Pimozide acts as an inhibitor of STAT3. Pimozide (0-15 μM) shows inhibitory of the proliferation of U2OS cells, with IC 50 value at 24, 48, and 72 h of 22.16 ± 2.54, 17.49 ± 1.14 and 13.78 ± 0.34 μM, respectively. Pimozide (10 μM) inhibits the colony- and sphere-forming abilities of osteosarcoma cells. Pimozide (15 μM) induces G0/G1 phase cell cycle arrest, suppresses the extracellular signal-regulated kinase (Erk) signaling to inhibit cell viability, and produces ROS generation through inhibiting antioxidant enzyme gene catalase expression in osteosarcoma cells. Pimozide acts as an inhibitor of STAT5. Pimozide reduces the expression of endogenous STAT5 target genes, and decreases STAT5 tyrosine phosphorylation.